Genomics, analysis and data management (Z02)

• Subject Area: Gastroenterology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 535081457

Next generation sequencing (NGS) has revolutionised molecular biology. We will customise NGS methods and implement robust frameworks for data management. We will develop innovative technologies such as single cell multi omics (scNMT-seq), combinatorial indexing for upscaling throughput, and spatial transcriptomics. Data will be integrated using machine learning across multi-omics modalities to uncover the molecular events, cellular crosstalk and spatial context driving MASLD. Our framework will help exploration of stage-specific events and drivers, and also empower projects to link key events in human MASLD to functional studies in mouse models of MASLD/MASH.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 412: Metabolic dysfunction-associated steatotic liver disease: Translating mechanisms to tailored therapeutic concepts
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Andreas Dahl; Professor Dr. Roland Eils