Project Details
Projekt
Tumor stroma-derived signals impair cDC1-dependent checkpoint inhibition as a potential resistance mechanism of colorectal cancer immunotherapy (P15)
Subject Area
Gastroenterology
Immunology
Immunology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631
Surprisingly, the contribution of dendritic cell subsets to the CRC TME is only incompletely understood. To this end, P15 aims to analyze the function of conventional dendritic cell 1 (cDC1) subset of tissue-residing cDCs and test the hypothesis that these cells contribute significantly to the resistance to check point inhibition of microsatellite stable colorectal cancers. Specific focus will be placed on the identification of signaling networks that regulate cDC1 and that could be therapeutically targeted to enhance responsiveness to immunotherapy.
DFG Programme
CRC/Transregios
Subproject of
TRR 417:
Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Kai Hildner
