The role of primary-CRC-derived adaptive immune cells in anti-metastasis immunity (P16)

• Subject Area: Immunology ; Gastroenterology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 540805631

P16 will examine a possible interconnection of the TME of a primary tumor and its metastases and assess whether adaptive immune cells such as B and T cells can shuttle and differentiate between a primary tumor and its metastases. Employing immunoinformatic data integration of transcriptome profiles and adaptive immune receptor sequences, the clonal relationship of different phenotypes of B and T cells will be characterized and will be linked to spatial transcriptomic and proteomic analyses to determine whether tumor-infiltrating lymphocytes in metastatic tissue may hold the potential to protect from metastasis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 417: Cellular Communication in the Stroma of Colorectal Cancer: From Pathophysiology to Clinical Translation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Stefan Fichtner-Feigl; Professorin Dr. Katharina Imkeller