Dissecting epithelial-immune cell interactions in Drosophila wounding

• Applicant: Professor Dr. Sven Bogdan
• Subject Area: Cell Biology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 564825258

Drosophila has emerged as a valuable genetic model for studying how a simple epithelium seals and how epithelial wounds repair by a series of events that integrate epithelial responses with those of resident and infiltrating immune cells. Here, we will use an advanced ‘extravasation’ Drosophila wounding model that allows us to screen for novel extravasation genes in real time in vivo. We will use this model to identify conserved key players and downstream events, which requires an intricate interplay between epithelial cells and infiltrating immune cells in response to damage and infection.

• DFG Programme: Priority Programmes
• Subproject of: SPP 2493: Heterotypic Cell-Cell Interactions in Epithelial Tissues (HetCCI)