SPACE - Quaternary structures of protein machines that utilize glycans (B03)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms ; Biochemistry ; Microbial Ecology and Applied Microbiology ; Structural Biology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 542264307

Protein complexes in marine bacteria may control the rate of glycan uptake and degradation, and thus the scale of carbon sequestration. We will elucidate how protein interactions and enzyme cascades help bacteria to cope with the variability of algal glycans. The project progresses from an examination of single protein functions to protein complexes. By investigating the structure, the spatial organization and function of glycan-degrading protein machineries, this project directly addresses the CONCENTRATE hypothesis of why some glycans resist degradation and contribute to carbon sequestration.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 420: Carbon sequestration at Å resolution - CONCENTRATE
• Applicant Institution: Universität Greifswald
• Project Heads: Professor Dr. Juri Rappsilber; Professor Dr. Thomas Schweder