LOCK – Recalcitrant glycans share common chemical structure motifs (B04)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 542264307

B4 LOCK will answer two questions regarding the intrinsic recalcitrance of glycans, (i) which chemical structure motifs resist or slow down microbial enzymatic degradation, and (ii) does primary-produced versus bacterially-transformed organic matter result in glycans of differential intrinsic recalcitrance? Guided by the hypothesis that intrinsically recalcitrant glycans share common chemical structure motifs, we will characterize at molecular resolution chemical structure motifs of these resistant glycans and thereby contribute to answer what are the unknown factors of glycan stability and degradation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 420: Carbon sequestration at Å resolution - CONCENTRATE
• Applicant Institution: Universität Greifswald
• Project Head: Professor Dr. Tilmann Harder