Super-resolution analysis of neuron-glia interplay at tripartite synapses (B12*)

• Subject Area: Human Genetics
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Our project will tackle three key questions: (1) How does the anatomy of the tripartite synapse look like at the nanoscale in living brain slices, i.e., free of fixation artifacts? (2) How does this nano-anatomy shape the transient bio-availability of signaling substances in the extracellular space in and around tripartite synapses? (3) How does synaptic activity affect or remodel the nano-anatomy of the tripartite synapse, and in turn impact the bio-availability of signaling substances, and thereby synaptic function?

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Urs Valentin Nägerl, Ph.D.