Project Details
Projekt
Mechanochemical coordination of tissue patterning and cellular dynamics (B13*)
Subject Area
Cell Biology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833
Morphogenesis and cell fate are orchestrated via biochemical and mechanical signals. Extracellular signal-related kinase (ERK) integrates these signals to drive cellular outcomes including proliferation, migration, and differentiation to build tissue complexity. How this multifactorial communication is decoded into ERK activity patterns that result in specific, correctly timed and positioned cellular behaviors remains unclear. Here we utilize live imaging, optogenetic tools, as well as mechanical measurements and manipulation to define how these signals are integrated in the context of skin morphogenesis at the single cell and tissue levels.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Dr. Leah Biggs, Ph.D.; Professorin Dr. Sara A. Wickström
