Project Details
Projekt
Mechanisms of neutrophil invasion across cellular membranes (B14*)
Subject Area
Cell Biology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833
Neutrophils are immune cells with the potential to invade almost any tissue compartment. Using live cell imaging, we will study neutrophils when they penetrate (a) endothelial cell surfaces during transcellular diapedesis, and (b) mast cell surfaces during mast cell intracellular trap formation. We focus on the roles of adhesion, plasma membrane and actin cortex properties for neutrophil invasion. This work aims at identifying molecular or mechanical pathways that underly critical cell-cell interactions during immune responses.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professor Dr. Tim Lämmermann, Ph.D.; Dr. Rebekka Stegmeyer
