Remote C(sp3)-H functionalization of aliphatic alcohols

• Applicant: Privatdozent Dr. Osama El-Sepelgy
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 571325623

Aliphatic alcohols are pivotal in synthetic intermediates and bioactive compounds, necessitating remote C(sp3)–H functionalization for their conversion into valuable chemical entities. However, widespread adoption of this method faces challenges like costly noble metal catalysts, chemical oxidants, high temperatures, and toxic solvents. Moreover, targeting tertiary C(sp3)−H bonds and achieving regiodivergent selectivity remain problematic. To address these hurdles, our initiative aims to devise a comprehensive strategy for remote functionalization. Our research program strives to pioneer eco-friendly, universally applicable catalytic systems for selectively functionalizing aliphatic C-H bonds in alcohol feedstocks. By leveraging earth-abundant base-metal catalysis and solar energy, we aim to achieve diverse remote functionalization of alcohols via radicals, unlocking numerous possibilities. The envisioned process entails catalyzing aliphatic functionalization with affordable base metals at ambient temperature, without the need for wasteful chemical oxidants. Through rigorous investigation employing spectroscopic and computational tools, we are confident that realizing this ambitious goal will pave the way for sustainable industrial practices with vast potential.

• DFG Programme: Research Grants