Characterisation of molecular resistance mechanisms against biological therapies in inflammatory bowel diseases (TP09)

• Subject Area: Gastroenterology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 550296805

In this project, we aim to decipher the molecular resistance mechanisms that drive therapeutic non-response to biological therapies in inflammatory bowel diseases (IBD). Here, we will functionally characterize gut macrophage populations involved in IL-23 production and analyze the extent to which IL-23R autocrine signaling events contribute to anti-TNF refractory IBD. Continuing on own findings, viral signatures concerning their functional role to regulate IL-23 production and IL-23R expression in gut macrophages will be studied to uncover their involvement in determining therapeutic response to biological therapy in IBD.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1755: CASCAID - Cellular and Systems Control of Autoimmune Disease
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Raja Atreya