The role of subcellular GPR65 signaling in immune cell function (26*)

• Subject Area: Immunology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 318346496

Our goal is to understand the function of GPR65 and its subcellular signaling landscape in various immune cell populations present in the tumor microenvironment, including B cells, natural killer cells, and different T cell subpopulations. To achieve this, we will conduct in vitro and in vivo experiments using newly generated GPR65 conditional knockout and reporter mice, as well as preclinical tumor models with varying acidification rates.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Andreas Bock; Dr. Toszka Bohn