Project Details
Projekt
Investigation, development and correlation of suitable ex-vivo and in-vivo models in the context of the biocompatibility of additive-manufactured permanent and resorbable materials in large animals
Applicant
Professor Dr. Ralf Smeets
Subject Area
Dentistry, Oral Surgery
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 449916462
In the project the large animal experiment for testing permanent implant materials is being carried out as part of the second funding period. The aim of the in vivo test is to assess the micromorphological effects of additively manufactured implant materials in the surrounding tissue, as well as the influence of different defect models and different service lives with regard to tissue-biomaterial interaction. The most-effective test specimens from the first funding period will be tested. Furthermore, the influence of tissue integration on the long-term stability of the implants and the implant-tissue interface will be characterized both in general and depending on the stage. The material focus of the second funding period is on resorbable biomaterial technologies such as magnesium. One focus is on the development of an intraoral ex-vivo wound model with the aim of simulating complex healing processes of the oral mucosa in a physiological environment. In this model, test specimens that do not meet the requirement profile for a later application of resorbable meshes will be excluded in a cascade. These results are to be used and transferred to the second large animal experiment with resorbable biomaterials such as magnesium, in which an intraoral defect model is to be developed in miniature pigs, which will make the results transferable to the later application of clinically relevant meshes. In the final year, the results of the ex-vivo and in-vivo experiments are correlated and compared.
DFG Programme
Research Units
Co-Investigator
Dr. Sandra Fuest
