The genomic landscape of non-obstructive azoospermia (A07)

• Subject Area: Human Genetics
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 549467913

Although many azoospermia-related genes have been identified in recent years, most affected men still remain without a causal diagnosis, precluding personalised treatment. The molecular mechanisms underlying azoospermia will, therefore, be elucidated. To this end, the significance of NXT2-interacting proteins as well as the novel X-linked candidate genes TKTL1 and KIAA1210 in male infertility will be explored. Further, the MERGE cohort will be expanded and novel in silico approaches will be employed to identify additional candidate genes for follow up. The results will be translated back into clinical practice to improve care for men with infertility.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1748: Principles of Reproduction – Unravelling the Molecular Mechanisms of Male Infertility
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Frank Tüttelmann