Molecular mechanisms of calcium signalling in human sperm (B03)

• Subject Area: Reproductive Medicine, Urology ; Cell Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 549467913

The flagellum of sperm serves not only as a propeller but also as sensory antenna. The flagellar ion channel CatSper translates changes in the environment into changes in swimming behaviour, enabling sperm to locate and fertilise the egg. To this end, CatSper seems to interplay with various other ion channels and molecules that are key for controlling sperm function. This project will unravel the molecular composition, physiological function, and pathophysiological relevance of the flagellar signalling pathways orchestrated by CatSper. This will shed light on the mechanisms underlying seemingly unexplained male infertility, enabling evidence-based treatment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1748: Principles of Reproduction – Unravelling the Molecular Mechanisms of Male Infertility
• Applicant Institution: Universität Münster
• Project Heads: Dr. Christoph Brenker; Professor Dr. Timo Strünker