Project Details
Projekt
Adherens junction and desmosome interactions in epithelial barriers in health and autoimmune disease (A01)
Subject Area
Cell Biology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789
The sub-project investigates how adherens junctions (AJs) and desmosomes (DSMs) coordinate their composition, stability, and turnover to regulate epithelial morphogenesis and regeneration in health and disease. Combining molecular force sensors and optomechanics with 2D, 3D, and in vivo models, we investigate the organization, mechanics, and function of AJs and DSMs at the molecular, cellular, and tissue levels in simple and stratified epithelia.
DFG Programme
CRC/Transregios
Applicant Institution
Philipps-Universität Marburg
Project Heads
Professor Dr. Carsten Grashoff; Professorin Dr. Carien Niessen
