Control of desmosome function by B-plexins (A02)

• Subject Area: Cell Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789

A02 analyzes the B-plexin-mediated regulation of desmosome ultrastructure and function using biochemical and functional assays and confocal and high-resolution microscopy, as well as signaling events downstream of B-plexins that are important for desmosome localization and function. The pathophysiological role of B-plexins is investigated in preclinical mouse models of pemphigus vulgaris.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 425: Desmosomal dysfunction in epithelial barriers (DEFINE)
• Applicant Institution: Philipps-Universität Marburg
• Project Heads: Dr. Thomas Schmitt; Professor Dr. Thomas Worzfeld