Project Details
Projekt
Contribution of early life microbial priming to desmosome-mediated barrier function in cutaneous and intestinal epithelia under steady-state and inflammatory conditions (A04)
Subject Area
Public Health, Healthcare Research, Social and Occupational Medicine
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789
A04 investigates the influence of prenatal microbial priming on desmosomal epithelial integrity in both healthy and inflamed states using organoids and murine imiquimod skin inflammation and colitis models. Human and murine epithelial cells from healthy and engineered skin and intestinal tissue will be used to generate 3D organoid models. Furthermore, targeted, microbiologically based interventions to restore damaged epithelial barriers will be developed.
DFG Programme
CRC/Transregios
Applicant Institution
Philipps-Universität Marburg
Project Heads
Dr. Mercedes Gomez de Agüero; Professor Dr. Benjamin Misselwitz
