Inflammatory signature in pemphigus (B01)

• Subject Area: Dermatology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789

B01 integrates extracellular vesicle (EV) profiling with functional T cell analyses to investigate their influence on epithelial skin structure and function in pemphigus vulgaris (PV). Using patient samples, in vitro and ex vivo organoid models, single-cell technologies, and a humanized PV model, the project aims to uncover core mechanisms of T cell processes in PV. Using a comparative approach with inflammatory bowel diseases (IBD), we aim to define common and tissue-specific pathways of immune-epithelial cell communication.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 425: Desmosomal dysfunction in epithelial barriers (DEFINE)
• Major Instrumentation: Spectral Flow Cell Analyzer
• Applicant Institution: Philipps-Universität Marburg
• Project Heads: Professor Dr. Michael Hertl; Dr. Anna Lena Jung