Regulation and modulation of T/B cell interactions, and implications of the IL-17/IL-23 axis in pemphigus (B02)

• Subject Area: Dermatology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789

Using high-dimensional single-cell technologies, accompanied by OLINK serum proteomics and tissue histology, B02 investigates (i) direct effects of type 17 cells and their secretome, (ii) indirect effects via the activation of B cells to autoantibody production by CXCR5+ follicular Th cells (Tfh) and CXCR5– peripheral Th cells (Tph), and (iii) altered counter regulation by Treg cells in the pathogenesis of pemphigus. These findings are validated in preclinical mouse models of PV.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 425: Desmosomal dysfunction in epithelial barriers (DEFINE)
• Applicant Institution: Philipps-Universität Marburg
• Project Heads: Professorin Dr. Magdalena Huber; Dr. Christian Möbs