Hyper-adhesion and mechanical stress to treat pemphigus (B05)

• Subject Area: Biophysics
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789

B05 will combine biochemical analyses with adhesion analyses and single-molecule force spectroscopy to determine the binding properties of desmosomal cadherins under specific adhesion conditions. Kinome and transcriptome analyses, as well as biochemical approaches, will identify common regulators of the adhesion spectrum and intercellular adhesion in pemphigus.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 425: Desmosomal dysfunction in epithelial barriers (DEFINE)
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professorin Dr. Franziska Hartig-Vielmuth