Project Details
Projekt
Regulation of barrier integrity by Armadillo proteins in digestive tract inflammation (C02)
Subject Area
Gastroenterology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789
The sub-project aims to elucidate the role of the epithelial plaque proteins JUP and PKP2 as critical regulators in the intestinal epithelium. To this end, mice with an inducible intestinal epithelial knockout of JUP (iVilCreERT2Jupfl/fl) and PKP2 (iVilCreERT2 Pkp2fl/fl) will be used, as well as derived organoids. In addition, a systematic analysis of the intestinal epithelium of patients with pathogenic genetic variants of desmosimal proteins will be conducted, including the generation of patient-derived organoids.
DFG Programme
CRC/Transregios
Applicant Institution
Philipps-Universität Marburg
Project Heads
Professorin Dr. Brenda Gerull; Privatdozent Dr. Matthias Kelm
