Role of desmosomal adhesion for wound healing and TJ formation for mucosal wound healing (C05)

• Subject Area: General and Visceral Surgery
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 547068789

This sub-project investigates the interactions and signaling pathways of desmosomal (DSM) and tight junction (TJ) proteins during intestinal wound healing. Sequential alterations of DSM and TJ are being investigated in various mouse models of wound healing. Furthermore, DSM proteins and the relevant signaling pathways are being modulated in murine intestinal organoids, and the effects on barrier repair and mucosal regeneration are being correlated with tissue samples and intestinal organoids from IBD patients.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 425: Desmosomal dysfunction in epithelial barriers (DEFINE)
• Applicant Institution: Philipps-Universität Marburg
• Project Heads: Privatdozent Dr. Sven Flemming; Dr. Cathérine Kollmann