Compartmentalized diversity of inflammatory GPCR networks in neurovascular disease (A06)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

Project A06 explores inflammatory G protein-coupled receptor networks (IGPNs) as drivers of neurovascular diseases, focusing on cerebral small vessel disease and intracranial atherosclerosis. It combines single-cell analyses including on human biosamples with studies on new experimental models to map spatial expression patterns of chemokines and lipid mediators. Functional analyses of candidate pathways such as MIF/CD74 and CXCL12/CXCR4 will reveal disease mechanisms and identify vascular zonation-specific IGPN components that could serve as novel anti-inflammatory targets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Jürgen Bernhagen; Professorin Dr. Sabine Steffens