Molecular and cellular mechanisms of T cell infiltration and activation in the lesion after ischemic stroke (B04)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

This project investigates how CD4+ T cell subsets infiltrate the brain after ischemic stroke and interact with resident immune cells in the lesion. It focuses on anatomical entry routes such as the meninges, choroid plexus, and parenchyma, and on the interaction with microglia, macrophages, and dendritic cells. Using intravital imaging and CRISPR-based gene editing, the project aims to identify molecular cues guiding T cell migration and activation that shape neuroinflammation and injury progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Dr. Corinne Benakis; Privatdozent Dr. Naoto Kawakami