Defining the interplay of vascular and glial cellular networks in response to neurovascular amyloidosis (C04)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

This project investigates how vascular and glial cellular networks respond to vascular amyloid deposition and how their interplay contributes to neurovascular dysfunction. It focuses on cellular interactions between mural cells, endothelial cells, and astrocytes in response to amyloid accumulation in small vessels. Using mouse models, in vivo imaging, and spatial transcriptomics, the project aims to identify mechanisms of impaired neurovascular signaling and determine whether modulating vascular-glial communication can mitigate disease progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Jonas Neher, Ph.D.; Privatdozentin Dr. Swetlana Sirko