Project Details
Projekt
Chemical-biology tools to release, sense, and study hydrogen sulfide as a trigger (A06)
Subject Area
Biological and Biomimetic Chemistry
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 550938463
Hydrogen sulfide (H2S) has been recognised to play an important role as an endogenously produced triggering molecule in various organisms. However, the molecular details of these H2S-signaling pathways are largely unexplored. In this project, novel synthetic molecules that release H2S upon a stimulus such as light irradiation, fluorescence probes for H2S that can be applied within living cells, and an improved workflow to reliably identify protein persulfidation by mass spectrometry are developed. These novel tools will then be employed to study H2S signaling and protein persulfidation in several prokaryotic model systems, and in the long run, also in eukaryotic model systems.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Konstanz
Project Heads
Professor David Schleheck, Ph.D.; Professor Dr. Valentin Wittmann
