Chemical and genetic tuning of protein dephosphorylation to augment trigger-induced immune responses (B03)

• Subject Area: Cell Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 550938463

Phosphorylation and dephosphorylation of proteins is a pivotal modality for trigger processing and de-regulated phosphorylation is a hallmark of several diseases. We will focus on metal-dependent protein phosphatases (PPMs) and systematically map the PPMs regulating the cellular response to soluble and particulate innate immune triggers. Using small molecule inhibitors and their chemical diversification we will precisely target key PPM phosphatases to augment cellular capabilities in innate immunity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1756: Chemical and Biological Principles of Cellular Trigger Responses
• Applicant Institution: Universität Konstanz
• Project Head: Professor Dr. Christof Robert Hauck