Comprehensive inference of transcriptional regulators involved in cellular trigger response (B07)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 550938463

The RNA expression regulators involved in cellular trigger response can be activated in various ways. To date there exists no experimental method that can measure activity changes of all the potentially involved regulators. In order to fill this critical gap, here we will implement a computational framework that will allow to infer regulator activities of all major RNA isoform expression regulation processes from standard RNA sequencing data. We will make the framework available to the community and use it to study the transcriptional regulators that drive Transforming Growth Factor Beta 1-triggered epithelial-to-mesenchymal transition.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1756: Chemical and Biological Principles of Cellular Trigger Responses
• Applicant Institution: Universität Konstanz
• Project Head: Professor Dr. Andreas Gruber, Ph.D.