ROS-Sensitive 1,2,3-Diazaborinine Prodrugs for Targeted Chemotherapy (C05)

• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 551403841

Project C05 “ROS-Sensitive 1,2,3-Diazaborinine Prodrugs for Targeted Chemotherapy” aims to develop a highly selective drug delivery system for targeted chemotherapy, based on the ROS-sensitivity of 1,2,3-diazaborinine-based boron cages. Using the anticancer agent camptothecin (CPT), the strategy combines the ROS-responsive prodrug concept with enzymatic tumor targeting. To enhance selectivity, the boron-caged prodrugs are linked to a modified enzyme that locally produces increased ROS levels.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1762: Boron as property-determining element
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Holger Braunschweig; Professor Dr. Lorenz Meinel