FOR 1082:  Biochemistry and biological function of Dnmt2 methyltransferases

• Fachliche Zuordnung: Biologie
• Förderung: Förderung von 2009 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 65636347

• Erstellungsjahr: 2016

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nature Genetics, Vol. 41. 2009, pp. 696–702.
  Phalke, Sameer; Nickel, Olaf; Walluscheck, Diana; Hortig, Frank; Onorati, Maria Cristina & Reuter, Gunter
  
• In vitro tRNA methylation assay with Entamoeba histolytica DNA and tRNA methyltransferase Dnmt2 (Ehmeth) enzyme. Journal of Visualized Experiments, Vol. 44. 2010: 2390.
  Tovy, Ayala; Hofmann, Benjamin; Helm, Mark & Ankri, Serge
  
• RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes & Development, Vol. 24.2010, pp. 1590-1595.
  Schaefer, Matthias; Pollex, Tim; Hanna, Katharina; Tuorto, Francesca; Meusburger, Madeleine; Helm, Mark & Lyko, Frank
  
• Glucose starvation boosts Entamoeba histolytica virulence. PLOS Neglected Tropical Diseases, Vol. 5. 2011, Issue 8, e1247.
  Tovy, Ayala; Hertz, Rivka; Siman-Tov, Rama; Syan, Sylvie; Faust, Daniela; Guillen, Nancy & Ankri, Serge
  
• Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. Journal of Biological Chemistry, Vol. 286. 2011, pp. 24200-24207.
  Jurkowska, Renata Z.; Rajavelu, Arumugam; Anspach, Nils; Urbanke, Claus; Jankevicius, Gytis; Ragozin, Sergey; Nellen, Wolfgang & Jeltsch, Albert
  
• Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Research, Vol. 40. 2012, Issue 22, pp. 11648–11658.
  Becker, Maria; Müller, Sara; Nellen, Wolfgang; Jurkowski, Tomasz P.; Jeltsch, Albert & Ehrenhofer-Murray, Ann E.
  
• RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nature Structural & Molecular Biology, Vol. 19. 2012, pp. 900–905.
  Tuorto, Francesca; Liebers, Reinhard; Musch, Tanja; Schaefer, Matthias; Hofmann, Sarah; Kellner, Stefanie; Frye, Michaela; Helm, Mark; Stoecklin, Georg & Lyko, Frank
  
• Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA). Nucleic Acids Research, Vol. 41. 2013, Issue 18, pp. 8615–8627.
  Muller, S.; Windhof, I. M.; Maximov, V.; Jurkowski, T.; Jeltsch, A.; Forstner, K. U.; Sharma, C. M.; Graf, R. & Nellen, W.
  
• The RNA methyltransferase Dnmt2 is required for efficient Dicer-2-dependent siRNA pathway activity in Drosophila. Cell Reports, Vol. 4. 2013, Issue 5, pp. 931-937.
  Durdevic, Zeljko; Mobin, Mehrpouya Balaghy; Hanna, Katharina; Lyko, Frank & Schaefer, Matthias
  
• Stress granule formation in Entamoeba histolytica: cross-talk between EhMLBP, EhRLE3 reverse transcriptase and polyubiquitinated proteins. Cellular Microbiology, Vol. 16. 2014, Issue 8, pp. 1211-1223.
  Katz, Sophia; Trebicz-Geffen, Meirav & Ankri, Serge
  
• The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. Nucleic Acids Research, Vol. 42. 2014, Issue 10, pp. 6487–6496.
  Shanmugam, Raghuvaran; Aklujkar, Muktak; Schäfer, Matthias; Reinhardt, Richard; Nickel, Olaf; Reuter, Gunter; Lovley, Derek R.; Ehrenhofer-Murray, Ann; Nellen, Wolfgang; Ankri, Serge; Helm, Mark; Jurkowski, Tomasz P. & Jeltsch, Albert
  
• Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine. Nucleic Acids Research, Vol. 43. 2015, Issue 22, pp. 10952–10962.
  Müller, Martin; Hartmann, Mark; Schuster, Isabelle; Bender, Sebastian; Thüring, Kathrin L.; Helm, Mark; Katze, Jon R.; Nellen, Wolfgang; Lyko, Frank & Ehrenhofer-Murray, Ann E.
  
• RNA 5-Methylcytosine Analysis by Bisulfite Sequencing. Methods in Enzymology, Vol. 560. 2015, pp. 297-329.
  Schaefer, Matthias
  
• Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress. PLOS Neglected Tropical Diseases, Vol. 10. 2016, Issue 1: e0004340.
  Shahi, Preeti; Trebicz-Geffen, Meirav; Nagaraja, Shruti; Alterzon-Baumel, Sharon; Hertz, Rivka; Methling, Karen; Lalk, Michael & Ankri, Serge