Assignment of the relative and absolute configuration of marine natural products using NMR spectroscopy and computational approaches

• Applicant: Privatdozent Dr. Matthias Koeck
• Subject Area: Analytical Chemistry
• Term: from 2008 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 44192252

The major goal of this project is the isolation and identification of new natural products applying NMR and computational methods to elucidate their structures, including the relative and absolute configuration as already described in the first application. The distance geometry approach will be extended to include RDCs since it is most suited for constitutionally diverse molecules. This, and the possibility for enantiomer differentiating alignment may ultimately lead to the determination of absolute configurations.

• DFG Programme: Research Units
• Subproject of: FOR 934: Relative and Absolute Configurations of Dissolved Molecules by NMR-Spectroscopy in Orienting Media
• Major Instrumentation: 1.7 mm probe for 400 NMR spectrometer
• Instrumentation Group: 1740 Hochauflösende NMR-Spektrometer