Gene-environment interactions, neural circuits and generalization in dimensional endophenotypes of fear and anxiety in adults and children: development and reversibility (Z02)

• Subject Area: Biological Psychiatry
• Term: from 2008 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 44541416

In its service function, 1.500 psychometrically, environmentally and (epi)genetically characterized adult volunteers and 500 catamnestically recruited children as well as an imaging backbone will be provided to all other experimental human B-/C-area subprojects. In its science function, the role of environmental factors, (epi)genetic factors, neural network markers and psychophysiological markers (conditioning, generalization) as well as their reversibility by a discrimination learning paradigm (de-generalization) will be investigated in anxiety-related phenotypes. Results are expected to contribute to a biomarker-guided individualized application of therapeutic and preventive modules derived from the concept of fear de-generalization.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 58: Fear, Anxiety, Anxiety Disorders
• Applicant Institution: Universität Münster
• Co-Applicant Institution: Julius-Maximilians-Universität Würzburg; Universität Hamburg
• Project Heads: Professor Dr. Udo Dannlowski; Professor Dr. Jürgen Deckert; Professorin Dr. Katharina Domschke, Ph.D.; Professorin Dr. Tina Barbara Lonsdorf; Professorin Dr. Ulrike Lüken; Professor Dr. Paul Pauli; Professor Dr. Marcel Romanos