GRK 1172:  Erforschung, Entwicklung und Sicherheit von Biopharmazeutika

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2005 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 814910

• Erstellungsjahr: 2016

Zusammenfassung der Projektergebnisse

Das Graduiertenkolleg hat eine herausragende Bedeutung für die nationale und internationale wissenschaftliche Sichtbarkeit des Standortes im Bereich der modernen Pharmaentwicklung. Es initiierte und stabilisierte eine langjährige enge Zusammenarbeit innerhalb der Fachbereiche der Goethe-Universität sowie mit den außeruniversitären Institutionen Georg-Speyer Haus, Blutspendedienst und dem Paul-Ehrlich-Institut Langen. Ein wenig aufwendiger war die Kooperation mit der Firma Merck KGaA aufgrund der mehrfachen Umorientierung der wissenschaftlichen Schwerpunkte und der damit verbundenen finanziellen Limitierungen. Die Attraktivität der weiter unten ausgeführten Graduiertenausbildung aber auch die Plattform für einen wissenschaftlichen Austausch führte zu einem großen Interesse auch nicht beteiligter Wissenschaftler, ihre PhD Studenten zu assoziieren. Diese Einbindung von 25 PhD Studenten gelang und war sicher einer der großen Erfolge des GRK. Darüber hinaus bauten einige PhD Studenten internationale Verbindungen mit z.B. dem Karolinska in Stockholm, dem NIH und einigen weiteren Institutionen auf. Obwohl eine genaue Quantifizierung der Zahl unabhängiger Publikationen und des genauen Impacts aufgrund der Beteiligung von mehreren PhD Studenten an gleichen Publikationen schwierig bleibt, resultierten doch etwa 3-4 Erst-/Koautorenschaften pro Doktorand im naturwissenschaftlichen Bereich und beeindruckende, mehr als 300 Originalarbeiten in ausgewiesenen internationalen Journalen.

Projektbezogene Publikationen (Auswahl)

• HIV-1 Vif: HIV’s weapon against the cellular defense factor APOBEC3G. Curr HIV Res. 2005 Oct;3(4):339-44
  Kremer M, Schnierle BS
  
• Human APOBEC3G incorporation into murine leukemia virus particles. Virology. 2005 Jun 20;337(1):175-82
  Kremer M, Bittner A, Schnierle BS
  
• Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris. Biochem J. 2006 Mar 15;394(Pt 3):563-73
  Giesübel U, Dälken B, Mahmud H, Wels WS
  
• Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired wounds. J Invest Dermatol. 2006 Mar;126(3):628-37
  Goren I, Kämpfer H, Müller E, Schiefelbein D, Pfeilschifter J, Frank S
  
• Vaccinia virus replication is not affected by APOBEC3 family members. Virol J. 2006 Oct 19;3:86
  Kremer M, Suezer Y, Martinez-Fernandez Y, Münk C, Sutter G, Schnierle BS
  
• A novel five-colour flow cytometric assay to determine NK cell cytotoxicity against neuroblastoma and other adherent tumour cells. J Immunol Methods. 2007 Aug 31;325(1-2):140-7
  Klöss S, Bochennek K, Huenecke S, Zimmermann SY, Kuçi S, Müller T, Wels WS, Klingebiel T, Esser R, Koehl U
  
• Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells. Virology. 2007 Aug 1;364(2):330-41
  Wolfrum N, Muehlebach MD, Schüle S, Kaiser JK, Kloke BP, Cichutek K, Schweizer M
  
• Multiple restrictions of human immunodeficiency virus type 1 in feline cells. J Virol. 2007 Jul;81(13):7048-60
  Münk C, Zielonka J, Constabel H, Kloke BP, Rengstl B, Battenberg M, Bonci F, Pistello M, Löchelt M, Cichutek K
  
• Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Dermatol. 2007 Sep;127(9):2259-67
  Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, Frank S
  
• The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. J Biol Chem. 2007 Jun 1;282(22):16006-15
  Ziesché E, Bachmann M, Kleinert H, Pfeilschifter J, Mühl H
  
• [Non-viral gene transfer results in therapeutic factor IX levels in haemophilia B mice]. Hamostaseologie. 2008 Oct;28 Suppl 1:S92-5. German
  Schüttrumpf J, Milanov P, Roth S, Seifried E, Tonn T
  
• Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis. Eur J Haematol. 2008 Jun;80(6):532-9
  Huenecke S, Behl M, Fadler C, Zimmermann SY, Bochennek K, Tramsen L, Esser R, Klarmann D, Kamper M, Sattler A, von Laer D, Klingebiel T, Lehrnbecher T, Koehl U
  
• Antitumour effects in mycosis fungoides of the immunomodulatory, tellurium-based compound, AS101. Br J Dermatol. 2008 Mar;158(3):578-86
  Frei GM, Kremer M, Hanschmann KM, Krause S, Albeck M, Sredni B, Schnierle BS
  
• Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. J Biol Chem. 2008 May 30;283(22):15479-90
  Schiefelbein D, Goren I, Fisslthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S
  
• Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair. Mol Pharmacol. 2008 Oct;74(4):952-63
  Schiefelbein D, Seitz O, Goren I, Dissmann JP, Schmidt H, Bachmann M, Sader R, Geisslinger G, Pfeilschifter J, Frank S
  
• Retroviral display and high throughput screening. Comb Chem High Throughput Screen. 2008 Feb;11(2):99-110
  Buchholz CJ, Duerner LJ, Funke S, Schneider IC
  
• T cells for suicide gene therapy: activation, functionality and clinical relevance. J Immunol Methods. 2008 Feb 29;331(1-2):69-81
  Hollatz G, Grez M, Mastaglio S, Quaritsch R, Huenecke S, Ciceri F, Bonini C, Esser R, Klingebiel T, Kreuter J, Koehl U
  
• Targeted cell entry of lentiviral vectors. Mol Ther. 2008 Aug;16(8):1427-36
  Funke S, Maisner A, Muehlebach MD, Koehl U, Grez M, Cattaneo R, Cichutek K, Buchholz CJ
  
• Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol. 2009 Mar;129(3):752-64
  Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, Frank S
  
• An RNA aptamer that induces transcription. Chem Biol. 2009 Feb 27;16(2):173-80
  Hunsicker A, Steber M, Mayer G, Meitert J, Klotzsche M, Blind M, Hillen W, Berens C, Suess B
  
• Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1408-13
  Zulauf L, Coste O, Marian C, Möser C, Brenneis C, Niederberger E
  
• Computer-aided analysis of cell interactions under dynamic flow conditions. Exp Dermatol. 2009 Mar;18(3):238-45. Erratum in: Exp Dermatol. 2009 Dec;18(12):1096
  Giegold O, Ludwig RJ, Hardt K, Will J, Schön MP, Oostingh GJ, Pfeilschifter JM, Boehncke WH, Radeke HH
  
• CXCL16 and oxLDL are induced in the onset of diabetic nephropathy. J Cell Mol Med. 2009 Sep;13(9B):3809-25
  Gutwein P, Abdel-Bakky MS, Doberstein K, Schramme A, Beckmann J, Schaefer L, Amann K, Doller A, Kämpfer- Kolb N, Abdel-Aziz AA, El Sayed el SM, Pfeilschifter J
  
• CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. Am J Pathol. 2009 Jun;174(6):2061-72
  Gutwein P, Abdel-Bakky MS, Schramme A, Doberstein K, Kämpfer-Kolb N, Amann K, Hauser IA, Obermüller N, Bartel C, Abdel-Aziz AA, El Sayed el SM, Pfeilschifter J
  
• Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol. 2009 Sep;157(3):370-6
  Ziesché E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Mühl H
  
• Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol. 2009 Sep;157(3):370-6
  Ziesché E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, Pfeilschifter J, Mühl H
  
• Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma. Biochem Biophys Res Commun. 2009 Mar 6;380(2):387-91
  Gutwein P, Schramme A, Voss B, Abdel-Bakky MS, Doberstein K, Ludwig A, Altevogt P, Hansmann ML, Moch H, Kristiansen G, Pfeilschifter J
  
• Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII. Thromb Haemost. 2009 Nov;102(5):925-35
  Heinz S, Schüttrumpf J, Simpson JC, Pepperkok R, Nicolaes GA, Abriss D, Milanov P, Roth S, Seifried E, Tonn T
  
• Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII. Thromb Haemost. 2009 Nov;102(5):925-35
  Heinz S, Schüttrumpf J, Simpson JC, Pepperkok R, Nicolaes GA, Abriss D, Milanov P, Roth S, Seifried E, Tonn T
  
• Induction of programmed cell death in ErbB2/HER2-expressing cancer cells by targeted delivery of apoptosis-inducing factor. Mol Cancer Ther. 2009 Jun;8(6):1526-35
  Mahmud H, Dälken B, Wels WS
  
• Mcl-1-mediated impairment of the intrinsic apoptosis pathway in circulating neutrophils from critically ill patients can be overcome by Fas stimulation. J Immunol. 2009 Nov 15;183(10):6198-206
  Paunel-Görgülü A, Zörnig M, Lögters T, Altrichter J, Rabenhorst U, Cinatl J, Windolf J, Scholz M
  
• Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol. 2009 Apr 1;182(7):4183-91
  Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH
  
• Optical imaging of cellular immunotherapy against prostate cancer. Mol Imaging. 2009 Jan-Feb;8(1):15-26
  Tavri S, Jha P, Meier R, Henning TD, Müller T, Hostetter D, Knopp C, Johansson M, Reinhart V, Boddington S, Sista A, Wels WS, Daldrup-Link HE
  
• Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth. Hepatology. 2009 Oct;50(4):1121-9
  Rabenhorst U, Beinoraviciute-Kellner R, Brezniceanu ML, Joos S, Devens F, Lichter P, Rieker RJ, Trojan J, Chung HJ, Levens DL, Zörnig M
  
• Protein scaffold and expression level determine antiviral activity of membraneanchored antiviral peptides. Hum Gene Ther. 2009 Apr;20(4):325-36
  Hermann FG, Martinius H, Egelhofer M, Giroglou T, Tonn T, Roth SD, Zahn R, Schult-Dietrich P, Alexandrov A, Dietrich U, Baum C, von Laer D
  
• Pseudotyping lentiviral vectors with the wild-type measles virus glycoproteins improves titer and selectivity. Gene Ther. 2009 May;16(5):700-5
  Funke S, Schneider IC, Glaser S, Muehlebach MD, Moritz T, Cattaneo R, Cichutek K, Buchholz CJ
  
• Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj. PLoS One. 2009 Sep 21;4(9):e7098
  Schüle S, Kloke BP, Kaiser JK, Heidmeier S, Panitz S, Wolfrum N, Cichutek K, Schweizer M
  
• Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. J Biol Chem. 2009 Feb 27;284(9):5819-26
  Perkovic M, Schmidt S, Marino D, Russell RA, Stauch B, Hofmann H, Kopietz F, Kloke BP, Zielonka J, Ströver H, Hermle J, Lindemann D, Pathak VK, Schneider G, Löchelt M, Cichutek K, Münk C
  
• The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158. Chembiochem. 2009 Jan 5;10(1):119-27
  Rehm S, Han S, Hassani I, Sokočević A, Jonker HR, Engels JW, Schwalbe H
  
• TLR2 ligands augment cPLA2alpha activity and lead to enhanced leukotriene release in human monocytes. J Leukoc Biol. 2009 Aug;86(2):389-99
  Lindner SC, Koehl U, Maier TJ, Steinhilber D, Sorg BL
  
• Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients. Eur J Cancer. 2009 Feb;45(3):478-89
  Gutwein P, Schramme A, Sinke N, Abdel-Bakky MS, Voss B, Obermüller N, Doberstein K, Koziolek M, Fritzsche F, Johannsen M, Jung K, Schaider H, Altevogt P, Ludwig A, Pfeilschifter J, Kristiansen G
  
• 5-Lipoxygenase inhibitors induce potent anti-proliferative and cytotoxic effects in human tumour cells independently of suppression of 5-lipoxygenase activity. Br J Pharmacol. 2010 Oct;161(4):936-49
  Fischer AS, Metzner J, Steinbrink SD, Ulrich S, Angioni C, Geisslinger G, Steinhilber D, Maier TJ
  
• 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. Front Pharmacol. 2010 Dec 24;1:143
  Steinhilber D, Fischer AS, Metzner J, Steinbrink SD, Roos J, Ruthardt M, Maier TJ
  
• ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. J Biomed Sci. 2010 Jan 13;17:3
  Gutwein P, Schramme A, Abdel-Bakky MS, Doberstein K, Hauser IA, Ludwig A, Altevogt P, Gauer S, Hillmann A, Weide T, Jespersen C, Eberhardt W, Pfeilschifter J
  
• ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. J Invest Dermatol. 2010 Mar;130(3):763-73
  Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P
  
• ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma. Biochem Biophys Res Commun.2010 Oct 22;401(3):363-9
  Ungerer C, Doberstein K, Bürger C, Hardt K, Boehncke WH, Böhm B, Pfeilschifter J, Dummer R, Mihic-Probst D, Gutwein P
  
• An improved bicistronic CD20/tCD34 vector for efficient purification and in vivo depletion of gene-modified T cells for adoptive immunotherapy. Mol Ther. 2010 Jul;18(7):1330-8
  Vogler I, Newrzela S, Hartmann S, Schneider N, von Laer D, Koehl U, Grez M
  
• CD271 antigen defines a subset of multipotent stromal cells with immunosuppressive and lymphohematopoietic engraftment-promoting properties. Haematologica. 2010 Apr;95(4):651-9
  Kuçi S, Kuçi Z, Kreyenberg H, Deak E, Pütsch K, Huenecke S, Amara C, Koller S, Rettinger E, Grez M, Koehl U, Latifi-Pupovci H, Henschler R, Tonn T, von Laer D, Klingebiel T, Bader P
  
• Cutaneous T-cell lymphoma cells are sensitive to rapamycin. Exp Dermatol. 2010 Sep;19(9):800-5
  Kremer M, Sliva K, Klemke CD, Schnierle BS
  
• Decreased HIV diversity after allogeneic stem cell transplantation of an HIV-1 infected patient: a case report. Virol J. 2010 Mar 8;7:55
  Kamp C, Wolf T, Bravo IG, Kraus B, Krause B, Neumann B, Winskowsky G, Thielen A, Werner A, Schnierle BS
  
• Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1. PLoS Pathog. 2010 Oct 14;6(10):e1001144
  Bachmann M, Horn K, Rudloff I, Goren I, Holdener M, Christen U, Darsow N, Hunfeld KP, Koehl U, Kind P, Pfeilschifter J, Kraiczy P, Mühl H
  
• Functional HIV-2- and SIVsmmPBjderived lentiviral vectors generated by a novel polymerase chain reaction-based approach. J Gene Med. 2010 May;12(5):446-52
  Kloke BP, Schüle S, Muehlebach MD, Wolfrum N, Cichutek K, Schweizer M
  
• Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med. 2010Feb;16(2):198-204
  Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Krämer A, Schwäble J, Glimm H, Koehl U, Preiss C, Ball C, Martin H, Göhring G, Schwarzwaelder K, Hofmann WK, Karakaya K, Tchatchou S, Yang R, Reinecke P, Kühlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C, Grez M
  
• IL-2- driven regulation of NK cell receptors with regard to the distribution of CD16+ and CD16- subpopulations and in vivo influence after haploidentical NK cell infusion. J Immunother. 2010 Feb-Mar;33(2):200-10
  Huenecke S, Zimmermann SY, Kloess S, Esser R, Brinkmann A, Tramsen L, Koenig M, Erben S, Seidl C, Tonn T, Eggert A, Schramm A, Bader P, Klingebiel T, Lehrnbecher T, Passweg JR, Soerensen J, Schwabe D, Koehl U
  
• IL-2-activated haploidentical NK cells restore NKG2D-mediated NK-cell cytotoxicity in neuroblastoma patients by scavenging of plasma MICA. Eur J Immunol. 2010;40(11):3255-67
  Kloess S, Huenecke S, Piechulek D, Esser R, Koch J, Brehm C, Soerensen J, Gardlowski T, Brinkmann A, Bader P, Passweg J, Klingebiel T, Schwabe D, Koehl U
  
• Inhibition of HIV-1 entry: multiple keys to close the door. ChemMedChem. 2010 Nov 8;5(11):1825-35
  Hertje M, Zhou M, Dietrich U
  
• Interleukin-22 detected in patients with abdominal sepsis. Shock. 2010 Oct;34(4):337-40
  Bingold TM, Ziesché E, Scheller B, Sadik CD, Franck K, Just L, Sartorius S, Wahrmann M, Wissing H, Zwissler B, Pfeilschifter J, Mühl H
  
• Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein. PLoS One. 2010 Dec 22;5(12):e14404
  Dälken B, Jabulowsky RA, Oberoi P, Benhar I, Wels WS
  
• Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein. PLoS One. 2010 Dec 22;5(12):e14404
  Dälken B, Jabulowsky RA, Oberoi P, Benhar I, Wels WS
  
• Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells. 2010 May;28(5):928-38
  Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B
  
• Multivariate analyses of immune reconstitution in children after allo-SCT: risk-estimation based on age-matched leukocyte sub-populations. Bone Marrow Transplant. 2010 Apr;45(4):613-21
  Koenig M, Huenecke S, Salzmann-Manrique E, Esser R, Quaritsch R, Steinhilber D, Radeke HH, Martin H, Bader P, Klingebiel T, Schwabe D, Schneider G, Lehrnbecher T, Orth A, Koehl U
  
• Nitric oxide mediates distinct effects of various LPS chemotypes on phagocytosis and leukotriene synthesis in human neutrophils. Int J Biochem Cell Biol. 2010 Jun;42(6):921-31
  Zagryazhskaya AN, Lindner SC, Grishina ZV, Galkina SI, Steinhilber D, Sud’ina GF
  
• Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors. Nat Methods. 2010 Nov;7(11):929-35
  Anliker B, Abel T, Kneissl S, Hlavaty J, Caputi A, Brynza J, Schneider IC, Münch RC, Petznek H, Kontermann RE, Koehl U, Johnston IC, Keinänen K, Müller UC, Hohenadl C, Monyer H, Cichutek K, Buchholz CJ
  
• Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cell Mol Life Sci. 2010 Mar;67(5):797-806
  Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ
  
• Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection. PLoS One. 2010 Aug 23;5(8):e12357
  Kimpel J, Braun SE, Qiu G, Wong FE, Conolle M, Schmitz JE, Brendel C, Humeau LM, Dropulic B, Rossi JJ, Berger A, von Laer D, Johnson RP
  
• TK.007: A novel, codon-optimized HSVtk(A168H) mutant for suicide gene therapy. Hum Gene Ther. 2010 Aug;21(8):929-41
  Preuss E, Treschow A, Newrzela S, Brücher D, Weber K, Felldin U, Alici E, Gahrton G, von Laer D, Dilber MS, Fehse B
  
• [Gene therapy for septic granulomatosis: risks and opportunities. The road to successful treatment of congenital immunodeficiency]. Pharm Unserer Zeit. 2011 May;40(3):264-71. German
  Schwäble J, Schultze-Strasser S, Stein S, Grez M
  
• A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm. Br J Pharmacol. 2011 Aug;163(8):1721-32
  : Revermann M, Mieth A, Popescu L, Paulke A, Wurglics M, Pellowska M, Fischer AS, Steri R, Maier TJ, Schermuly RT, Geisslinger G, Schubert-Zsilavecz M, Brandes RP, Steinhilber D
  
• Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse. J Immunol Methods. 2011 Oct 28;373(1-2):36-44
  Bremm M, Huenecke S, Lehrnbecher T, Ponstingl E, Mueller R, Heinze A, Bug G, Quaiser A, Kapinsky M, Brehm C, Bader P, Schneider G, Klingebiel T, Koehl U
  
• Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse. J Immunol Methods. 2011 Oct 28;373(1-2):36-44
  Bremm M, Huenecke S, Lehrnbecher T, Ponstingl E, Mueller R, Heinze A, Bug G, Quaiser A, Kapinsky M, Brehm C, Bader P, Schneider G, Klingebiel T, Koehl U
  
• Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse. J Immunol Methods. 2011;373(1-2):36-44
  Bremm M, Huenecke S, Lehrnbecher T, Ponstingl E, Mueller R, Heinze A, Bug G, Quaiser A, Kapinsky M, Brehm C, Bader P, Schneider G, Klingebiel T, Koehl U
  
• Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther. 2011 Jan;19(1):122-32
  Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, Bueren JA, Grez M, Thrasher AJ
  
• Biophysical characterization of α-amylase inhibitor Parvulustat (Z-2685) and comparison with Tendamistat (HOE-467). Biochim Biophys Acta. 2011 Oct;1814(10):1383-93
  Sokočević A, Han S, Engels JW
  
• Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect. J Mol Med (Berl). 2011 Nov;89(11):1113-24
  Preuss E, Muik A, Weber K, Otte J, von Laer D, Fehse B
  
• Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect. J Mol Med (Berl). 2011 Nov;89(11):1113-24
  Preuss E, Muik A, Weber K, Otte J, von Laer D, Fehse B
  
• Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites. Retrovirology. 2011 Mar 23;8:21
  Kraus B, Boller K, Reuter A, Schnierle BS
  
• Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems. Mol Biotechnol. 2011 Mar;47(3):262-9
  Grabski E, Waibler Z, Schüle S, Kloke BP, Sender LY, Panitz S, Cichutek K, Schweizer M, Kalinke U
  
• Depicting adoptive immunotherapy for prostate cancer in an animal model with magnetic resonance imaging. Magn Reson Med. 2011 Mar;65(3):756-63
  Meier R, Golovko D, Tavri S, Henning TD, Knopp C, Piontek G, Rudelius M, Heinrich P, Wels WS, Daldrup-Link H
  
• Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia. J Infect Dis. 2011 Feb 1;203(3):430-5
  Schmidt S, Tramsen L, Hanisch M, Latgé JP, Huenecke S, Koehl U, Lehrnbecher T
  
• IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study. PLoS One. 2011;6(11):e27351
  Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker PS, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, Koehl U
  
• IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study. PLoS One. 2011;6(11):e27351
  Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker PS, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, Koehl U
  
• IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study. PLoS One. 2011;6(11):e27351
  Brehm C, Huenecke S, Quaiser A, Esser R, Bremm M, Kloess S, Soerensen J, Kreyenberg H, Seidl C, Becker PS, Mühl H, Klingebiel T, Bader P, Passweg JR, Schwabe D, Koehl U
  
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