Astrocyte-to-neuron communication: functional relevance for synaptic transmission in the respiratory network?

• Antragsteller: Professor Dr. Swen Hülsmann
• Fachliche Zuordnung: Molekulare Biologie und Physiologie von Nerven- und Gliazellen
• Förderung: Förderung von 2008 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 82921243

• Erstellungsjahr: 2011

Zusammenfassung der Projektergebnisse

Astrocytes in the respirator network have important function for transmitter uptake and extracellular potassium regulation. In the pre-Bötzinger complex astrocytes appear to be special in the sense that they do not accumulate SR101. Functionally they appear to do not show activity dependent calcium signalling as long as they are capable to eliminate glutamate from the extracellular space. Thus astrocytic calcium signalling is, however, observed when glutamate transport processes in astrocytes are suppressed or neuronal discharge activity is excessive.

Projektbezogene Publikationen (Auswahl)

• (2009) Astrocytic calcium signals induced by neuromodulators via functional metabotropic receptors in the ventral respiratory group of neonatal mice. Glia, Vol. 57. 2009, Issue 8, pp. 815–827.
  Härtel K., C. Schnell, S. Hülsmann