Universitätsklinikum Aachen, AöR
Institut für Medizinische Mikrobiologie
Address
Pauwelsstraße 30
52074 Aachen
Deutschland
GERiT
This institution in GERiT
52074 Aachen
Projects
Research Fellowships
Completed projects
Toll-ähnliche Rezeptoren und ihre Bedeutung bei der gastrointestinalen Entzündungsreaktion
(Applicant
Hornef, Mathias Walter
)
Research Grants
Current projects
Dissecting the role of cholesterol trafficking in pathogen-containing vacuole stability
(Applicant
Selkrig, Joel
)
Functional impact of bile acids conversion by the gut microbiome on colorectal cancer
(Applicant
Clavel, Thomas
)
Personalized effects of antibiotics on the human gut microbiome via high-throughput cultivation
(Applicants
Clavel, Thomas
;
Maier, Lisa
)
Completed projects
Between vigilance and tolerance: Innate immune signaling at the intestinal epithelium
(Applicant
Hornef, Mathias Walter
)
Functional analysis of gut microbiome-host interactions during the postnatal window of opportunity by a multiscale sequencing approach
(Applicants
Clavel, Thomas
;
Hornef, Mathias Walter
;
Horz, Hans-Peter
;
Pabst, Oliver
)
Functions and metabolic adaptation of dominant gut bacteria of the family Coriobacteriaceae in the context of host lipid metabolism
(Applicants
Clavel, Thomas
;
Rohn, Sascha
)
Global analysis of saliva as a source of bacterial DNA - a potential chronometer for human population and migration studies
(Applicant
Horz, Hans-Peter
)
Homeostatic and infection-induced adaptive immunity in the neonatal small intestine and its functional consequences
(Applicant
Torow, Ph.D., Natalia
)
Host control of persistent Salmonella infection
(Applicants
Hornef, Mathias Walter
;
Pabst, Oliver
)
Host-pathogen interaction in a novel in vivo model of enteropathogenic Escherichia coli (EPEC) infection
(Applicant
Dupont, Ph.D., Aline
)
Mechanisms that prevent inappropriate Toll-like receptor activation at the intestinal epithelium
(Applicant
Hornef, Mathias Walter
)
The in vivo response of the intestinal epithelium to bacterial infection
(Applicant
Hornef, Mathias Walter
)
Priority Programmes
Current projects
Bacterial and host factors governing enterocyte exit of Salmonella
(Applicant
Hornef, Mathias Walter
)
Cooperative pathogenicity of enteropathogenic E. coli (EPEC) within mucosa-attached microcolonies
(Applicants
Dupont, Ph.D., Aline
;
Saliba, Antoine-Emmanuel
;
Sauer, Markus
)
Ecology and functions of small SCIFF proteins in the gut microbiome
(Applicants
Clavel, Thomas
;
Gulder, Tobias A. M.
)
Completed projects
Host control of the enteric microbiota during the postnatal period
(Applicant
Hornef, Mathias Walter
)
In vivo Formation and Maintenance of Salmonella-Containing Vacuoles (SCVs) in Enterocytes using a Novel Neonatal Mouse Model
(Applicant
Hornef, Mathias Walter
)
- MIMIC - Culture-based and molecular study of the mouse gut microbiome towards Minimal Microbial Consortia
(Applicants
Clavel, Thomas
;
Overmann, Jörg
)
Collaborative Research Centres
Current projects
Enterohepatic cooperation in the postnatal establishment of immune homeostasis
(Project Head
Hornef, Mathias Walter
)
Functional analysis of lipid metabolism by the microbiome in gut-liver interactions
(Project Heads
von Bergen, Martin
;
Clavel, Thomas
)
Functional microbiome analysis
(Project Heads
Blank, Ph.D., Lars
;
Clavel, Thomas
)
Gnotobiotic mouse models and minimal bacterial consortia
(Project Heads
Basic, Marijana
;
Bleich, André
;
Clavel, Thomas
;
Haller, Dirk
)
Integrated Research Training Group ‘Gut-Liver Axis’
(Project Heads
Hornef, Mathias Walter
;
Liedtke, Christian
)
Navigation abilities of gut commensals and their modulation in the gut-liver axis
(Project Head
Grognot, Marianne
)
Targeted design and manipulation of minimal bacterial consortia for strain replacement within microbiomes
(Project Heads
Clavel, Thomas
;
Stecher, Barbara
)
Completed projects
Mechanisms of host-bacteria homeostasis on the intestinal epithelium
(Project Head
Hornef, Mathias Walter
)
The role of antimicrobial peptides for the establishment and maintenance of the intestinal host-microbe homeostasis
(Project Head
Hornef, Mathias Walter
)
Clinical Research Units
Current projects
Impact of Disease Burden and Timing of Disease Initiation on the Response to Interferonalpha (IFNa) in MPN-associated myelofibrosis
(Applicants
Koschmieder, Steffen
;
Torow, Ph.D., Natalia
)
KFO 344: Untangling and Targeting Mechanisms of Myelofibrosis in Myeloproliferative Neoplasms (MPN)
(Spokesperson
Brümmendorf, Tim Henrik
)
Major Research Instrumentation
Completed projects
Platform for the automated isolation and characterization of anaerobic bacteria
CRC/Transregios
Current projects
Nutrition, host metabolism and the antimicrobial response to enteric infection in the neonatal host
(Project Head
Hornef, Mathias Walter
)
Perinatal crosstalk of microbiota and intestinal macrophages in the control of mucosal pathogens
(Project Heads
Clavel, Thomas
;
Erny, Daniel
;
Henneke, Philipp
)
International Research Training Groups
Completed projects
GRK 1273: Strategies of Human Pathogens to Establish Acute and Chronic Infections
(Spokesperson
Suerbaum, Sebastian
)
NFDI technical and methodological consortia
Current projects
NFDI4Microbiota - National Research Data Infrastructure for Microbiota Research
(Spokesperson
Förstner, Konrad
)
