Ludwig-Maximilians-Universität München
Biomedizinisches Centrum München
Immunologie
Address
Großhaderner Straße 9
82152 Planegg
Deutschland
GERiT
This institution in GERiT
82152 Planegg
Projects
Heisenberg Fellowships
Completed projects
Immunologie
(Applicant
Brocker, Thomas
)
Research Fellowships
Completed projects
Einfluß der Tumorprogression auf Tumor-spezifische T-Zellen in einem transgenen Modell
(Applicant
Klein, Ludger
)
Funktion von Calcineurin und Isoenzymen der Proteinkinase C bei der T-Zell-Entwicklung
(Applicant
Obst, Reinhard
)
Molecular mechanisms of LFA-1 signaling involved in the priming phase of cytotoxic T lymphocytes by different DC subtypes
(Applicant
Stutte, Susanne
)
Untersuchung der Signaltransduktion in der Induktion von T-Zell Toleranz
(Applicant
Heissmeyer, Vigo
)
Research Grants
Current projects
Exploring unique and redundant functions of m6A-recognizing RNA-binding proteins in T cells
(Applicant
Heissmeyer, Vigo
)
Mechanisms of CD4+ T Cell Exhaustion by Persistent Antigen and Chronic Inflammation
(Applicant
Obst, Reinhard
)
The role of Cathepsin L in shaping a functional T cell repertoire
(Applicant
Klein, Ludger
)
Completed projects
Aire-expressing lymph node cells
(Applicant
Klein, Ludger
)
Analysis of the hepatitis C virus specific CD4+ T cell response in different phases of chronic hepatitis C using novel HLA class II tetramers.
(Applicant
Ulsenheimer, Axel
)
Antigen Targeting in plasmazytoide dendritische Zellen - Nutzung zur Toleranzinduktion und Vakzinierung
(Applicant
Krug, Anne
)
Autophagy in thymic epithelium and T cell tolerance
(Applicant
Klein, Ludger
)
Connecting E3 ligase and mRNA decay functions of Roquin proteins
(Applicant
Heissmeyer, Vigo
)
Control of development and tolerogenic properties of thymic epithelial cells by micro RNAs
(Applicant
Klein, Ludger
)
Control of T cell tolerance and regulation through NFAT complex formation
(Applicant
Heissmeyer, Vigo
)
Der Mechanismus antigenunabhängiger Proliferation von CD8+ T-Zellen
(Applicant
Obst, Reinhard
)
Determining the molecular mechanism and functional importance of Eri1-dependent histone mRNA degradation
(Applicant
Heissmeyer, Vigo
)
Exploring the tolerogenic function of medullary thymic epithelial cells using tissue-specific knockdown in transgenic mice
(Applicant
Klein, Ludger
)
Functional adaptation of intrathymically differentiating B cells for central T cell tolerance
(Applicant
Klein, Ludger
)
How Chronic Antigen Presentation Compromises CD4+ T Cell Memory
(Applicant
Obst, Reinhard
)
Regulation of RIG-I signaling by a a novel interferon-inducible short form of RIG-I
(Applicant
Krug, Anne
)
RNA-binding proteins and control of mRNA metabolism in the regulation of adaptive immunity in humans
(Applicant
Heissmeyer, Vigo
)
The influence of antigen distribution on quality and repertoire of CD8+ T cell responses
(Applicant
Brocker, Thomas
)
The role of CCL17 and CCL17-expressing dendritic cells in intestinal Inflammation
(Applicant
Krug, Anne
)
The role of cross presentation in viral infection
(Applicant
Brocker, Thomas
)
The role of Interleukin-1 associated kinase 1 in intestinal inflammation
(Applicant
Krug, Anne
)
The role of microRNAs in dendritic cell development and function
(Applicant
Brocker, Thomas
)
UNDERSTANDING THE MECHANISM OF YELLOW FEVER 17D VACCINE EFFICACY: AN IMMUNO-STRUCTURAL APPROACH TOWARDS THE DESIGN OF A PAN-FLAVIVIRUS VACCINE
(Applicants
Krug, Anne
;
Rothenfußer, Simon
)
Untersuchung der Rolle von bcl-2 Expression in dendritischen Zellen bei Induktion und Regulierung der Immunantwort in vivo
(Applicant
Brocker, Thomas
)
Independent Junior Research Groups
Completed projects
Plasmazytoide dendritische Zellen und Toll-like Rezeptoren - Funktion bei systemischer Autoimmunität
(Applicant
Krug, Anne
)
Heisenberg Professorships
Completed projects
Dendritic cells and innate immune receptors in the context of immunity and inflammation in the intestine
(Applicant
Krug, Anne
)
Collaborative Research Centres
Current projects
Cell-Fate Decision Analysis Platform
(Project Heads
Heissmeyer, Vigo
;
Kranich, Jan
;
Richter, Lisa
;
Schroeder, Ph.D., Timm
)
Central Tasks of the Collaborative Research Centre
(Project Head
Brocker, Thomas
)
Dendritic cell control of T cell differentiation and immune responses by exosomes
(Project Head
Brocker, Thomas
)
Dendritic cell precursor fate and function in steady state and viral infection
(Project Head
Krug, Anne
)
Determinants of Intrathymic T-Cell Fate Decisions
(Project Head
Klein, Ludger
)
Integrated Research Training Group "Cell-Fate Decisions in the Immune System"
(Project Head
Klein, Ludger
)
Post-transcriptional gene regulation in T cell activation, effector function and memory formation
(Project Head
Heissmeyer, Vigo
)
SFB 1054: Control and Plasticity of Cell-Fate Decisions in the Immune System
(Spokesperson
Brocker, Thomas
)
Completed projects
Analyse tolerogener Dendritischer Zellen: Manipulierung des Reifestadiums durch transkriptionelles "Targeting" in vivo
(Project Head
Brocker, Thomas
)
A Phenotypic and molecular roadmap of regulatory T cell development
(Project Head
Klein, Ludger
)
CD40 Signaltransduktion durch den TRAF Proteinkomplex: Dissektion pro- und anti-apoptotischer Signale auf Signalproteinebene
(Project Head
Engelmann, Ph.D., Hartmut
)
Control of T cell tolerance and regulation through NFAT complex formation
(Project Head
Heissmeyer, Vigo
)
Entwicklung rekombinanter hochaffiner CD4-C1-Varianten als additive Therapeutika zu Reserve Transkriptase- und Preotease-Inhibitoren im Rahmen der antiretroviralen Kombinantionstherapie
(Project Heads
Kufer, Peter
;
Riethmüller, Gert
)
Function of the endothelial cell adhesion melecule MCAM CD146 in the development and manifestation of tissue specific autoimmune disease
(Project Head
Johnson, Judith P.
)
Funktion des Zelladhäsionsmoleküls MCAM
(Project Head
Johnson, Judith P.
)
Modulation of regulatory T cells by endogenous TLR ligands and DC
(Project Head
Krug, Anne
)
On the role of cross-presenting Dendritic Cells in T cell tolerance induction
(Project Head
Brocker, Thomas
)
Populationsgenetische und funktionelle Untersuchungen zur HIV Resistenz des Allels HLA-A69 und anderer resistenz-assoziierter Allele sowie von HLA-Allelen, die mit Progression assoziiert sind
(Project Head
Wank, Rudolf
)
Poxvirus Infection Model and Vaccine Development
(Project Head
Brocker, Thomas
)
Regulation of T cell responsesby autoantigen
(Project Head
Obst, Reinhard
)
Rho-GTPase-dependent plasmacytoid dendritic cell seeding, retention and recruitment in vivo
(Project Heads
Brocker, Thomas
;
Stutte, Susanne
)
Selektive Modulation der Immunogenität von Tumorzellen mit Hilfe bifunktioneller Antikörperkonstrukte
(Project Heads
Kufer, Peter
;
Riethmüller, Gert
)
Spezifische Induktion dominanter T Zelltoleranz durch intrathymischen Transfer modifizierter thymischer Epithel-Vorläuferzellen
(Project Head
Klein, Ludger
)
TCR Tuning by Transient and Persistent Antigen Presentation
(Project Head
Obst, Reinhard
)
The role of steady-state MHC class I - CD8 T cell interaction in proliferative capacity and repertoire diversity
(Project Head
Brocker, Thomas
)
Untersuchungen zur Induktion von Immunität, Toleranz und Autoimmunität durch Dendritische Zellen in vivo
(Project Head
Brocker, Thomas
)
Virus-vermittelte Aktivierung und Hemmung dendritischer Zellfunktion
(Project Head
Krug, Anne
)
Priority Programmes
Completed projects
Differential protein- and RNA-interactions of Roquin specify alternative modes of post-transcriptional gene regulation
(Applicants
Heissmeyer, Vigo
;
Niessing, Dierk
)
CRC/Transregios
Current projects
Defining predictors of anti-viral immunity in the yellow fever vaccination model using gene polymorphisms and early innate response patterns
(Project Heads
Krug, Anne
;
Rothenfußer, Simon
)
Inter- and intramolecular cross-regulation during CNS autoimmunity
(Project Head
Klein, Ludger
)
Post-transcriptional control of metabolic programs that improve T cell responses against tumors
(Project Head
Heissmeyer, Vigo
)
Post-transcriptional control of tissue-resident regulatory T cells
(Project Head
Heissmeyer, Vigo
)
Research Training Groups
Completed projects
GRK 303: Infection and Immunity
(Spokesperson
Heesemann, Jürgen
)
GRK 1482: Interface Functions of the Intestine between Luminal Factors and Host Signals
(Spokesperson
Haller, Dirk
)
Graduate Schools
Completed projects
GSC 1006: Graduate School of Quantitative Biosciences Munich (QBM)
(Spokesperson
Frey, Erwin
)