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Institution
Charité - Universitätsmedizin Berlin
Charité Campus Mitte
Institut für Medizinische Physik und Biophysik
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Priority Programmes
Completed projects
Deaktivierung der visuellen Kaskade - Proteininteraktionen und stochastische Simulation
(Applicant
Hofmann, Klaus Peter
)
G-Protein/Effektor-Interaktion in der visuellen Kaskade - Mechanismus und Kinetik
(Applicant
Hofmann, Klaus Peter
)
Research Grants
Current projects
Structural and functional analysis of the yeast heterochromatin complex SIR
(Applicants
Ehrenhofer-Murray, Ann Elizabeth
;
Spahn, Christian M. T.
)
Translation and its regulation in different compartments of the plant cell
(Applicant
Spahn, Christian M. T.
)
Completed projects
A chemical and synthetic biology approach for post-trancriptional gene regulatory networks and therapeutic generation
(Applicant
Guillen Schlippe, Ph.D., Yollete
)
Bedeutung der ribosomalen E-Stelle für GTP-Verbrauch und Erhaltung des Leserasters während der Translation
(Applicant
Nierhaus, Knud Hermann
)
Die Universalität des ribosomalen Dreistellen-Models und nicht-kanonische Translationsfaktoren: Untersuchung ihrer Funktionen und Strukturanalyse durch Kryo-EM
(Applicant
Nierhaus, Knud Hermann
)
Funktionelle Charakterisierung von Centrinen und deren Wechselwirkungen mit heterotrimeren G-Proteinen
(Applicants
Pulvermüller, Alexander
;
Wolfrum, Uwe
)
Mechanism of Arrestin Activation and GPCR Binding
(Applicant
Heck, Martin
)
Rolle des Phospholipids in der visuellen Signaltransduktion: Retinalaustausch und blaulichtinduzierte Apoptose
(Applicant
Hofmann, Klaus Peter
)
Semisynthese von Rhodopsin
(Applicant
Hofmann, Klaus Peter
)
Structural analysis of a transducisome in photoreceptor rod cells by cryo-electron microscopy
(Applicant
Spahn, Christian M. T.
)
Structural and biochemical analyses of the disproportionating isozyme 2 (DPE2)
(Applicants
Mielke, Thorsten
;
Spahn, Christian M. T.
)
Research Units
Current projects
FOR 5930: Autoantibodies against G protein-coupled receptors as drivers of vasculopathies (AbsInVasc)
(Spokesperson
Riemekasten, Gabriela
)
P4 - Deciphering the interaction and functional patterns of GPCR autoantibodies
(Applicants
Catar, Rusan
;
Riemekasten, Gabriela
;
Scheerer, Patrick
)
Completed projects
Coordination of the Research Unit 1805
(Applicant
Ignatova, Zoya
)
FOR 1805: Ribosome Dynamics in Regulation of Speed and Accuracy of Translation
(Spokesperson
Ignatova, Zoya
)
Translational GTPases and the energy landscape of the 70S ribosome
(Applicant
Spahn, Christian M. T.
)
Collaborative Research Centres
Current projects
Peptide synthesis and membrane protein (GPCR) expression
(Project Heads
Beck-Sickinger, Annette G.
;
Scheerer, Patrick
)
Structural elucidation of activity regulation at GPCRs involved in metabolism and immune responses
(Project Head
Scheerer, Patrick
)
Structures of adhesion GPCR by cryo-electron microscopy
(Project Heads
Scheerer, Patrick
;
Schöneberg, Torsten
;
Spahn, Christian M. T.
)
Completed projects
Central tasks
(Project Heads
Hofmann, Klaus Peter
;
Spahn, Christian M. T.
)
Chromophore-protein interaction in the signaling state of rhodopsin
(Project Heads
Bartl, Franz
;
Hofmann, Klaus Peter
)
Die Schnittstelle zwischen Signaltransduktion und Retinalstoffwechsel beim Sehvorgang
(Project Heads
Heck, Martin
;
Hofmann, Klaus Peter
)
Elektronenkristallographische Untersuchungen von licht-aktiviertem Rhodopsin
(Project Heads
Hofmann, Klaus Peter
;
Mielke, Thorsten
)
Molecular electron microscopy
(Project Heads
Mielke, Thorsten
;
Spahn, Christian M. T.
)
Proton-coupled conformational changes in photoreceptors
(Project Heads
Hildebrandt, Peter
;
Scheerer, Patrick
)
Renoprotection by understanding functional and structural G-protein-coupled receptor activation
(Project Heads
Dragun, Duska
;
Scheerer, Patrick
)
SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
(Spokespersons
Hofmann, Klaus Peter
;
Spahn, Christian M. T.
)
Signalzustände von Rezeptoren
(Project Head
Hofmann, Klaus Peter
)
Structural and functional examinations of nucleotide-dependent membrane scaffolds
(Project Heads
Daumke, Oliver
;
Spahn, Christian M. T.
)
Structural elucidation of the GPCR allosteric machine
(Project Heads
Hildebrand, Peter
;
Scheerer, Patrick
)
Structure and dynamics eukaryotic 80S ribosomes during the elongation phase of protein synthesis
(Project Head
Spahn, Christian M. T.
)
Structure-based identification of optimized mutant Kir3.4 inhibitors for renoprotection
(Project Heads
Scheerer, Patrick
;
Scholl, Ute
)
Strukturanalyse eines Transducisoms in Photorezeptor Stäbchenzellen mit Kryoelektronen-Mikroskopie
(Project Heads
Heck, Martin
;
Hofmann, Klaus Peter
;
Spahn, Christian M. T.
)
Strukturuntersuchungen an solubilisiertem Rhodopsin und funktionellen Komplexen mit der Flüssigphasen-NMR-Spektroskopie
(Project Heads
Hofmann, Klaus Peter
;
Oschkinat, Hartmut
)
The regeneration-module in photoreceptor cells
(Project Heads
Heck, Martin
;
Hofmann, Klaus Peter
)
The role of rhodopsin oligomers in the amplifier submodule of retinal rods
(Project Heads
Ernst, Oliver-Peter
;
Hofmann, Klaus Peter
)
Three-dimensional cryo-electron microscopy
(Project Head
Spahn, Christian M. T.
)
Major Research Instrumentation
Completed projects
300 kV Cryo-Transmission Electron Microscope for tomography
Correlative cryo-light microscope (cryo-LM)
Focused Ion Beam Scanning Electron Microscope
Research Training Groups
Completed projects
GRK 268: Dynamics and Evolution of Cellular and Macromolecular Systems
(Spokesperson
Heinrich, Reinhart
)
GRK 276: Signal Recognition and Transduction
(Spokesperson
Wiedenmann, Bertram
)
Clusters of Excellence
Completed projects
EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
(Spokesperson
Schmitz, Dietmar
)
Clusters of Excellence (ExStra)
Current projects
EXC 2008: UniSysCat
(Spokespersons
Mroginski, Ph.D., Maria Andrea
;
Rappsilber, Juri
;
Thomas, Arne
)
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