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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Fakultät
Institut für Pathologie
Address
Venusberg-Campus 1
53127 Bonn
Deutschland
GERiT
This institution in GERiT
53127 Bonn
Projects
Research Grants
Current projects
Establishment and Analysis of Actin-like 7b deficient mice – a tool to study male factor infertility.
(Applicant
Schorle, Hubert
)
Molecular and spatial dissection of endothelial cell heterogeneity in clear cell renal cell carcinoma
(Applicants
Hölzel, Michael
;
Toma, Marieta
)
Protamine1/Protamine-2 double deficient male mice. Detailed analysis of infertility using ChiP-seq on histones of sperm and scRNA-seq. on early embryos to detail the epigenetic disturbances leading to aberrant gene -reactivation.
(Applicant
Schorle, Hubert
)
Understanding the molecular biology of sperm calyx: biochemical and genetic analyses using Cylicin1, Cylicin1 and Calicin deficient mice
(Applicants
Schneider, Simon
;
Schorle, Hubert
)
Completed projects
Analyses of the consequences of a protamine-2-deficiency in mouse and man: molecular mechanisms, reactive oxygen species and an approach to therapy.
(Applicants
Schorle, Hubert
;
Steger, Klaus
)
Characterization of trefoil factor-3 as a novel chemokine - evaluation of its function in immune cell differentiation and infiltration of prostate carcinoma
(Applicant
Nowak, Michael
)
Die Bedeutung des Ets 1 Transkriptionsfaktors in der Regulation der Tumorinvasion
(Applicant
Wernert, Nicolas
)
Die Interaktion von Connexin31 und AP-2gamma in der Trophoblast "lineage" Differenzierung für die Erhaltung des Stammzellpotenzials der Trophoblastzellen während der Plazentadifferenzierung
(Applicants
Schorle, Hubert
;
Winterhager, Elke
)
Die Regulation der Genexpression während der fetalen Spermatogenese im Vergleich zu gestörter Spermatogenese und Keimzelltumoren
(Applicant
Schorle, Hubert
)
Function and biomedical implications of myoglobin in breast cancer
(Applicants
Hankeln, Thomas
;
Kristiansen, Glen
)
Funktionelle Analysen von Ets-Transkriptionsfaktoren sowie Ets-Fusionstranskripten in Prostatakarzinomen
(Applicant
Wernert, Nicolas
)
Genetische Mechanismen der Invasion und Metastasierung von Kolonkarzinomen
(Applicant
Büttner, Reinhard
)
Human kallikreins 14 and 15 as new biomarkers of prostate carcinoma
(Applicant
Jung, Klaus
)
Mikrodissektionsbasierte Analyse der Genexpression in der Prostata und dem Prostatakarzinom
(Applicant
Wernert, Nicolas
)
Molecular mechanisms of direct reprogramming of fibroblasts to trophoblast stem cells
(Applicants
Schorle, Hubert
;
Schultze, Joachim L.
)
On the role of AP-2 transcription-factors: Molecular and developmental biological experiments
(Applicant
Schorle, Hubert
)
Role of a Neuropilin-2/CXCR4 signaling pathway in the formation of prostate cancer bone metastases
(Applicants
Dubrovska, Anna
;
Hofbauer, Lorenz C.
;
Muders, Michael Helmut
)
The role of cleaved-protamine 2 in sperm chromatin dynamics.
(Applicant
Arevalo, Lena
)
The role of the PGC master regulators Blimp1, Prdm14 and Tfap2c on the licensing of germ cells - control of pluripotency and channeling into unipotency
(Applicant
Schorle, Hubert
)
Untersuchung zur Rolle von AP-2delta und AP-2epsilon und die Onkogen-Kooperation von AP-2gamma und erbB2
(Applicant
Schorle, Hubert
)
Research Fellowships
Completed projects
Entwicklung neuer therapeutischer Ansätze des exokrinen Pankreasadenokarzinoms durch Blockade der Signalmoleküle des IGF-1-Rezeptors IRS-2, PKCdelta sowie Expressionsveränderung von Tsc-2 und Modulation von mTOR in vitro und in vivo
(Applicant
Muders, Michael Helmut
)
Collaborative Research Centres
Completed projects
Biophysikalische Untersuchungen zur Lipidspezifität membranaktiver antimikrobieller Peptide/Proteine der epithelialen Abwehr
(Project Head
Seydel, Ulrich
)
Molekulare Aspekte der Aktivierung von Monozyten/Makrophagen durch bakterielle Virulenzfaktoren: Beteiligung von Ionenkanälen
(Project Heads
Schromm, Andra B.
;
Seydel, Ulrich
)
CRC/Transregios
Completed projects
Histopathological platform for analysis of hepatic and renal fibrosis
(Project Heads
Boor, Ph.D., Peter
;
Fischer, Hans-Peter
;
Franklin, Bernardo
;
Kristiansen, Glen
;
Longerich, Thomas
)
Additional Information
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