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Julius-Maximilians-Universität Würzburg
Biozentrum der Universität Würzburg
Lehrstuhl für Biochemie und Molekularbiologie

Address Am Hubland
97074 Würzburg
Deutschland

GERiT This institution in GERiT

97074 Würzburg

Projects

Priority Programmes
- Completed projects
  - Regulation of the cdk inhibitor, p27 Regulation des cdk inhibitor, p27
    (Applicant Eilers, Martin )
Research Units
- Completed projects
  - FOR 2314: Targeting therapeutic windows in essential cellular processes for tumor therapy
    (Spokesperson Zender, Lars )
  - Role of Miz1 in the Atr/Chk1 signalling pathway and in Myc-induced apoptosis
    (Applicant Eilers, Martin )
  - ShRNA Screening and Histopathology
    (Applicants Eilers, Martin ; Rosenwald, Andreas ; Zender, Lars )
  - Targeting MYC-driven hepatocellular carcinoma via Aurora-A ligands
    (Applicants Eilers, Martin ; Laufer, Stefan ; Zender, Lars )
  - Targeting MYC in pancreatic cancer
    (Applicant Eilers, Martin )
Clinical Research Units
- Completed projects
Research Grants
- Current projects
  - Multimerization of MYC proteins as oncogenic principle
    (Applicant Eilers, Martin )
  - MYCN-dependent Transcription Termination and Stress Resilience of Transcription
    (Applicant Eilers, Martin )
- Completed projects
  - Myc-dependent apoptosis as a tumor-suppressive mechanism: how do cells discriminate between physiological and oncogenic levels of Myc expression?
    (Applicant Eilers, Martin )
  - Rolle des Zink-Finger-Proteins Miz-1 in der Tumorigenese und in der Kontrolle der Proliferation von Keratinozyten und Lymphozyten
    (Applicant Eilers, Martin )
Collaborative Research Centres
- Current projects
  - The role of chromosome topology in MYCN function and neuroblastoma evolution and its potential for clinical exploitation
    (Project Heads Eilers, Martin ; Papadopoulos, Dimitrios )
- Completed projects
  - Compartmentaion of Myc Degradation
    (Project Head Eilers, Martin )
  - Mechanismus der Genaktivierung und -repression von Myc
    (Project Heads Eilers, Martin ; Lutz, Werner )
  - Rolle des Zink-Finger Proteins Miz-1 in der Transformation durch Myc und der Embryonalentwicklung der Maus
    (Project Head Eilers, Martin )
  - Rolle von Myc und Miz1 in der Neurogenese im Zentralnervensystem
    (Project Head Eilers, Martin )
Major Research Instrumentation
- Completed projects
CRC/Transregios
- Current projects
  - Engineering of CAR-T cells that overcome MYC-dependent immunosuppression in a genetically engineered mouse model of pancreatic cancer
    (Project Heads Danhof, Sophia ; Eilers, Martin )
- Completed projects
  - Administration of the Transregio and Coordination of Activities
    (Project Heads Eilers, Martin ; Schartl, Ph.D., Manfred )
  - Role of FoxO proteins in oncogene co-operation
    (Project Head Eilers, Martin )
  - Role of the Myc/Miz1 interaction in the co-operation of Ras and Myc
    (Project Heads Eilers, Martin ; Elsässer, Hans-Peter ; Wanzel, Michael )
  - TRR 17: Ras-dependent Pathways in Human Cancer
    (Spokesperson Eilers, Martin )
Research Training Groups
- Current projects
  - GRK 2243: Understanding Ubiquitylation: From Molecular Mechanisms To Disease
    (Spokesperson Buchberger, Alexander )
International Research Training Groups
- Completed projects
  - GRK 767: Transcriptional Control in Developmental Processes
    (Spokesperson Suske, Guntram )
Graduate Schools
- Completed projects
  - GSC 106: Graduate School for Life Sciences (GSLS)
    (Spokesperson Kisker, Caroline )

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