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Universitätsklinikum Tübingen
Medizinische Universitätsklinik
Abteilung Innere Medizin VIII

Address Otfried-Müller-Straße 14
72076 Tübingen
Deutschland

GERiT This institution in GERiT

72076 Tübingen

Projects

Research Grants
- Current projects
  - Deciphering the molecular pathogenesis of Cushing's disease
    (Applicants Fassnacht, Martin ; Popov, Nikita ; Sbiera, Ph.D., Silviu )
  - Identification of novel therapeutic strategies for molecular subtypes of gastric cancer
    (Applicant Leibold, Josef )
  - LXRα induced lipotoxicity for cancer treatment
    (Applicant Dauch, Ph.D., Daniel )
  - Multimodal therapy approaches for NUT carcinoma (NC)
    (Applicant Lauer, Ulrich M. )
- Completed projects
Emmy Noether International Fellowships
- Completed projects
  - Untersuchungen von genetischen Interaktionen und Mechanismen der Chemotherapieresistenz in mittels shRNAs generierten epithelialen Tumoren im 3D Zellkulturmodell und im Mausmodell
    (Applicant Zender, Lars )
Independent Junior Research Groups
- Current projects
  - Biochemical and mechanistical elucidation of inflammasomes – the key players of chronic inflammation
    (Applicant Andreeva, Liudmila )
- Completed projects
  - Identifizierung von neuen Tumorsuppressornetzwerken im HCC durch integrative onkogenomische Analyse und in vivo RNAi screens
    (Applicant Zender, Lars )
Research Units
- Completed projects
  - Coordination Funds
    (Applicant Zender, Lars )
  - FOR 2314: Targeting therapeutic windows in essential cellular processes for tumor therapy
    (Spokesperson Zender, Lars )
  - Inhibierung von HECT-Ligasen zur Krebstherapie
    (Applicants Laufer, Stefan ; Lorenz, Sonja Gisela ; Popov, Nikita )
  - ShRNA Screening and Histopathology
    (Applicants Eilers, Martin ; Rosenwald, Andreas ; Zender, Lars )
  - Targeting lipid synthesis and NADPH regeneration in cancer
    (Applicants Dauch, Ph.D., Daniel ; Schulze, Almut )
  - Targeting MYC-driven hepatocellular carcinoma via Aurora-A ligands
    (Applicants Eilers, Martin ; Laufer, Stefan ; Zender, Lars )
  - Targeting oncoprotein stability for cancer therapy
    (Applicants Kisker, Caroline ; Popov, Nikita )
  - Targeting Rpa3 for cancer treatment
    (Applicants Dauch, Ph.D., Daniel ; Laufer, Stefan )
  - Therapeutic Induction and Image Guided Exploitation of Cellular senescence for Cancer Therapy
    (Applicants Pichler, Bernd ; Zender, Lars )
Collaborative Research Centres
- Completed projects
  - Oncolysis-based multimodal concepts for breaking resistance to therapy in GI oncology
    (Project Head Lauer, Ulrich M. )
  - Senescence surveillance in the liver-mechanistic dissection and therapeutic development
    (Project Head Zender, Lars )
Research Fellowships
- Completed projects
  - Functional in vivo characterisation of the role of epigenetic regulators for pancreatic cancer development and maintenance
    (Applicant Leibold, Josef )
CRC/Transregios
- Completed projects
  - Combinatorial targeting of epigenetic mechanisms in liver cancer
    (Project Heads Bitzer, Michael ; Dauch, Ph.D., Daniel )
  - Functional genetic dissection of hepatocarcinogenesis in NASH
    (Project Heads Rudalska, Ramona ; Zender, Lars )
  - Identification of molecular mechanisms conferring resistance to oncolytic viruses in HCC and implications for successful HCC virotherapy
    (Project Heads Eggert, Tobias ; Kühnel, Florian ; Lauer, Ulrich M. )
  - RANi Screening for Synthetic Lethalities and Treatment Response Modifiers of Targeted Therapies in Hepatocellular Carcinoma
    (Project Heads Geffers, Ph.D., Robert ; Zender, Lars )
  - The role of platelets in premetastatic niche formation and metastasis
    (Project Heads Borst, Oliver ; Zender, Lars )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2180: Image-Guided and Functionally Instructed Tumor Therapies (iFIT)
    (Spokespersons Pichler, Bernd ; Rammensee, Hans-Georg ; Walz, Juliane ; Zender, Lars )

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