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Ruprecht-Karls-Universität Heidelberg
Biochemie-Zentrum (BZH)

Address Im Neuenheimer Feld 328
69120 Heidelberg
Deutschland

GERiT This institution in GERiT

69120 Heidelberg

Projects

Priority Programmes
- Completed projects
Research Grants
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Independent Junior Research Groups
- Current projects
  - LOTUS domain proteins in transposon silencing and translation control
    (Applicant Jeske, Mandy )
  - Towards the molecular mechanism of membrane fission mediated by the ESCRT-III/Vps4 machinery
    (Applicant Moser von Filseck, Joachim )
- Completed projects
  - Genetische und molekulare Analyse circadianer Rhythmen in Drosophila melanogaster
    (Applicant Weber, Frank )
Research Units
- Current projects
- Completed projects
  - Characterization of the translocation pore of the peroxisomal protein import machinery
    (Applicants Erdmann, Ralf ; Meinecke, Michael )
  - FOR 1905: Structure and Function of the Peroxisomal Translocon (PerTrans)
    (Spokesperson Erdmann, Ralf )
  - Structural, physiological and pathogenic features of APP/APLPs E1 domain
    (Applicants Kins, Stefan ; Wild, Klemens )
  - Structure and function of YidC and homologous membrane proteins
    (Applicant Sinning, Irmgard )
Reinhart Koselleck Projects
- Completed projects
  - Aufklärung der Ribosomen-Entstehung durch den Einsatz eines thermophilen Eukaryonten
    (Applicant Hurt, Eduard Christian )
Collaborative Research Centres
- Current projects
  - Central Administration
    (Project Head Meinecke, Michael )
  - Cryo-EM and cryo-correlative approaches to study membrane remodelling
    (Project Heads Chlanda, Petr ; Paulino, Cristina )
  - ESCRT-III-mediated membrane remodelling in Archaea and Eukarya
    (Project Head Moser von Filseck, Joachim )
  - Information Infrastructure for SFB1638
    (Project Heads Kopp, Jürgen ; Sinning, Irmgard )
  - Mechanical and chemical crosstalk between membranes and anchored mechano-kinases
    (Project Heads Gräter, Frauke ; Nickel, Walter )
  - Mechanisms of Endoplasmic Reticulum morphogenesis
    (Project Head Schuck, Sebastian )
  - Mechanisms of Wnt protein secretion
    (Project Heads Boutros, Michael ; Sinning, Irmgard )
  - Membrane remodelling during mitochondrial lipid transfer
    (Project Head Meinecke, Michael )
  - Molecular Dynamics Simulations of Membrane Systems
    (Project Heads Gräter, Frauke ; Lolicato, Fabio )
  - Molecular mechanism driving disulfide formation during FGF2 oligomerization and membrane translocation
    (Project Heads Dick, Tobias ; Nickel, Walter )
  - Roles of lipids in Wnt secretion and signaling
    (Project Heads Boutros, Michael ; Brügger, Britta )
  - SFB 1638: Cellular membrane remodelling – how changing form creates function
    (Spokesperson Meinecke, Michael )
  - Spatial lipidomics and targeted lipid analytics
    (Project Heads Brügger, Britta ; Hopf, Carsten )
  - Structure-function analysis of lipid remodelling in tail-anchored protein insertion into the ER membrane
    (Project Head Sinning, Irmgard )
  - Synaptic exocytosis: dynamic molecular arrangements and intermediates on the path to lipid bilayer merger
    (Project Head Söllner, Thomas )
  - Systematic analysis of ER-shaping Reticulon and REEP proteins
    (Project Head Schlaitz, Anne-Lore )
  - Uncovering novel molecular mechanisms within Wnt signaling
    (Project Heads Sinning, Irmgard ; Özbek, Suat )
- Completed projects
  - Biogenese und Funktion von Peroxisomen
    (Project Head Just, Wilhelm )
  - Biogenese von Peroxisomen
    (Project Head Just, Wilhelm )
  - Central tasks of the Collaborative Research Centre
    (Project Head Wieland, Felix Wilhelm Theodor )
  - Charakterisierung der Biogenese und der nukleären Exportwege von tRNA in Hefe
    (Project Head Hurt, Eduard Christian )
  - Die Rolle von Kernporenproteinen und löslichen Transportfaktoren beim Export von mRNA aus dem Zellkern ins Zytoplasma
    (Project Head Hurt, Eduard Christian )
  - Dynamics of COPI Assembly
    (Project Heads Brügger, Britta ; Wieland, Felix Wilhelm Theodor )
  - ER-assoziierte Proteinfaltung, Degradation und Regulation der Chaperonexpression
    (Project Head Haas, Ingrid G. )
  - Formation, Maturation and Nuclear Export of mRNPs
    (Project Head Hurt, Eduard Christian )
  - Functional analysis of membrane remodeling by epsin1
    (Project Head Meinecke, Michael )
  - Functional regulation of the mitochondrial presequence translocation complex
    (Project Head Meinecke, Michael )
  - Geschäftsführung
    (Project Head Wieland, Felix Wilhelm Theodor )
  - HTP-Protein crystallization platform and X-ray structure determination
    (Project Head Sinning, Irmgard )
  - Membrane lipids and proteins in influenza replication and spread
    (Project Heads Brügger, Britta ; Kräusslich, Hans-Georg )
  - Molecular Mechanism of Clathrin-Independet Endocytic Budding at the Plasma Membrane
    (Project Head Geli, Maria Isabel )
  - Molecular mechanisms of ribosome associated enzymes in stress response
    (Project Head Sinning, Irmgard )
  - Molekualre Mechanismen der bildung von Transportvesikeln
    (Project Heads Nickel, Walter ; Wieland, Felix Wilhelm Theodor )
  - Molekulare Analyse des Kinetochors von Saccharomyces cerevisiae
    (Project Head Lechner, Johannes )
  - mTOR-dependent sensing of translation stress in Neurospora crassa
    (Project Head Brunner, Michael )
  - Plasmamembran-Transport und Externalisierung von Leishmania HASPB: ein Zelloberflächenfaktor mit unmittelbarer Bedeutung für Wirtszellinfektion und die intrazelluläre Überlebensfähigkeit von Leishmania Parasiten
    (Project Head Nickel, Walter )
  - Protein analysis by mass spectrometry
    (Project Heads Lechner, Johannes ; Ruppert, Thomas )
  - Quantitative Bestimmung im pMol Maßstab und Charakterisierung des Enzyms Glucosylceramid Synthase
    (Project Head Jeckel, Dieter )
  - Regulation des SRP-Systems und Röntgenstruturanalyse seiner Komponenten
    (Project Head Sinning, Irmgard )
  - SFB 352: Molecular Mechanisms of Intracellular Transport
    (Spokesperson Wieland, Felix Wilhelm Theodor )
  - SFB 638: Dynamics of Macromolecular Complexes in Biosynthetic Transport
    (Spokesperson Wieland, Felix Wilhelm Theodor )
  - Structural and functional analysis of thiol redox proteins in trypanosomes
    (Project Head Krauth-Siegel, R. Luise )
  - Structural dynamics of coatomer
    (Project Heads Briggs, John ; Wieland, Felix Wilhelm Theodor )
  - Structure and dynamics of protein complexes in tail-anchored membrane protein biogenesis
    (Project Head Sinning, Irmgard )
  - Structure and Dynamics of Protein/RNA complexes in SRP-mediated protein transport
    (Project Heads Sinning, Irmgard ; Wild, Klemens )
  - Structure, Function and Reconstitution of the Nuclear Pore Complex
    (Project Heads Flemming, Dirk ; Hurt, Eduard Christian )
  - Synthetische N-Glykosylakzeptor-Analoga zur in vivo Untersuchung der N-Glykosylierung im Endoplasmatischen Reticulum
    (Project Head Knappe, Joachim )
  - Temporal and spatial dynamics of the circadian clock of Neurospora
    (Project Head Brunner, Michael )
  - Thiol-dependent redox networks as targets of antimalarial agents
    (Project Heads Dandekar, Thomas ; Schirmer, Heiner )
  - Unconventional Protein Secretion
    (Project Head Nickel, Walter )
  - Zentralprojekt Massenspektrometrie - Quantitative Analyse von Membranlipiden
    (Project Heads Brügger, Britta ; Wieland, Felix Wilhelm Theodor )
CRC/Transregios
- Current projects
  - A cargo de-ubiquitination switch in membrane remodeling in the endocytic pathway
    (Project Head Moser von Filseck, Joachim )
  - Central Coordination
    (Project Heads Freund, Christian ; Nickel, Walter )
  - Central Tasks of the Transregional Collaborate Research Centre
    (Project Head Söllner, Thomas )
  - Chemical biology and lipidomics for molecular switches
    (Project Heads Brügger, Britta ; Johnsson, Kai )
  - Control of organelle biogenesis by the Lipin switch
    (Project Heads Daumke, Oliver ; Schuck, Sebastian )
  - High resolution analysis of active zone cytomatrix remodeling
    (Project Heads Paulino, Cristina ; Schultz, Carsten ; Sigrist, Stephan J. ; Walter, Alexander )
  - Molecular insights into the role of MTREC in ncRNA processing and degradation
    (Project Head Sinning, Irmgard )
  - Molecular switches in the spatio-temporal coordination of the FGF2 membrane translocation machinery
    (Project Heads Ewers, Helge ; Lolicato, Fabio ; Nickel, Walter )
  - Neurotransmitter release: spatio-temporal characterization of membrane fusion intermediates
    (Project Heads Rosenmund, Christian ; Söllner, Thomas )
  - Phosphoswitches controlling the timing of the circadian clock of Neurospora by modulation of long-range interactions
    (Project Heads Brunner, Michael ; Herzel, Hanspeter ; Milles, Sigrid )
  - The palmitoylation switch in activated T cells
    (Project Heads Brügger, Britta ; Freund, Christian )
  - TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission
    (Spokespersons Freund, Christian ; Nickel, Walter )
- Completed projects
  - Lipid transport across membrane contact sites
    (Project Head Höglinger, Doris )
  - Molecular machinery mediating FGF2 membrane translocation in unconventional secretion
    (Project Head Nickel, Walter )
  - Role of lipids in membrane protein insertion
    (Project Head Sinning, Irmgard )
  - Specific interactions of lipids with protein transmembrane segments
    (Project Heads Brügger, Britta ; Wieland, Felix Wilhelm Theodor )
  - Specific Lipid Interactions of Transmembrane Segments of Membrande Proteins
    (Project Heads Brügger, Britta ; Wieland, Felix Wilhelm Theodor )
  - Specific Lipid Interactions of Transmembrane Segments of Membrane Proteins
    (Project Heads Brügger, Britta ; Wieland, Felix Wilhelm Theodor )
  - STARD3 as a cellular switch determining organelle contact sites
    (Project Head Höglinger, Doris )
  - The role of membrane microdomains in membrane fusion
    (Project Head Söllner, Thomas )
  - TRR 83: Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies
    (Spokesperson Söllner, Thomas )
Major Research Instrumentation
- Completed projects
  - Hybrid-Massenspektrometer
Research Training Groups
- Completed projects
  - GRK 230: Molecular Cell Biology
    (Spokesperson Dobberstein, Bernhard )
  - GRK 300: Pathogenic Microorganisms: Molecular Mechanisms and Genomic Approaches
    (Spokesperson Clayton, Christine Elizabeth )
  - GRK 1188: Quantitative Analysis of Dynamic Processes in Membrane Transport and Translocation
    (Spokespersons Fackler, Ph.D., Oliver T. ; Nickel, Walter )
Clusters of Excellence
- Completed projects
  - EXC 81: Cellular Networks: From Analysis of Molecular Mechanisms to a Quantitative Understanding of Complex Functions (CellNetworks)
    (Spokesperson Kräusslich, Hans-Georg )
Graduate Schools
- Completed projects
  - GSC 249: The Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology
    (Spokesperson Wittbrodt, Joachim )

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