Project Details
Projekt
Molecular imaging with innovative and approved tracers to resolve tumor heterogeneity and predict therapeutic outcome (B02)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
from 2009 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 68647618
Molecular imaging techniques providing a better representation of the tumor-mass and resolving tumor heterogeneity are in urgent demand to improve the poor prognosis of brain tumor (glioma) patients. Therefore, we investigate combinatorial imaging by PET, MRI and optoacoustic coupling in preclinical models faithfully recapitulating distinct genetic and pathological subsets of gliomas. Our approach will delineate the individual strength of each imaging-procedure in localizing pathologically relevant tumor-areas and will provide new information for treatment-planning and -monitoring. In particular we use imaging tracers indicating invasive, angiogenic and metabolically conspicuous tumor-fields and determine the impact of blood-brain barrier integrity in our imaging modalities.
DFG Programme
Collaborative Research Centres
Applicant Institution
Technische Universität München (TUM)
Project Heads
Professorin Dr. Nathalie Albert; Professor Dr. Rainer Glass
