GRK 1715:  Molecular Signatures of Adaptive Stress Responses

• Subject Area: Medicine
• Term: from 2012 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 177710919

• Final Report Year: 2022

Final Report Abstract

"All things are poison and nothing is without poison, only the dose permits something not to be poisonous" - the famous dictum of Paracelsus is of formidable relevance in modern medicine and biology. Organisms are perpetually facing noxious insults but exhibit surprising diverse reaction patterns. Depending on the strength, frequency and quality of the stress stimuli biological individuals may react with increased vitality, future stress resistance or with injury and degeneration. Whereas a multitude of such specific stress responses has been observed in diverse biological systems the underlying molecular mechanisms are largely unknown. Our Research Training Group explored specific signalling reactions controlling the ambivalent reaction patterns of cells and organisms to stressful challenges. Adaptive responses to defined stress stimuli were analysed in a dose- and time-resolved manner. In the first funding period the results of our RTG significantly added to the understanding of the molecular reaction patterns of biological systems towards dose-dependent effects of stress. In the second funding period investigations of the dynamics of adaptive stress responses were considerably intensified. Specific use of advanced animal models of selected diseases allowed efficient exploitation of the results in prophylaxis and treatment of modern medicine. These efforts contributed to strengthening the collaborative research projects on Sepsis and Ageing within the research focus “Life” at in Jena. In conjunction with research groups from the Medical Faculty and the Faculty of Biological Sciences of the FSU and of the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) the RTG fostered cross-disciplinary PhD research projects in this innovative field of life sciences. As a main goal, the RTG aimed to provide young scientists with insight into the intimate interrelationship between fundamental biological phenomena such as life and death, disease and recovery and the underlying complex molecular processes. The wide spectrum of cellular and organismic models used by the participating groups afforded a deeper understanding of the dynamic reaction patterns of biological systems challenged by external insults. In order to reach these goals, the study programme of the RTG offered a multifaceted series of lectures, meetings, seminars and workshops as well as placements in laboratories of international cooperation partners. The RTG is affiliated with the Jena School of Molecular Medicine (JSMM), a certified member of the FSU Jena Graduate Academy.

Publications

• (2012) Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle. 10: 1411-1419
  Zhong, Jianing; Liao, Ji; Liu, Xin; Wang, Pei; Liu, Jinping; Hou, Wenya; Zhu, Bingtao; Yao, Lu; Wang, Jinsheng; Li, Jing; Stark, Jeremy M.; Xie, Yuntao & Xu, Xingzhi
  
• (2012) Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation. Cell Signal. 24: 1453-1460
  Ginter, Torsten; Bier, Carolin; Knauer, Shirley K.; Sughra, Kalsoom; Hildebrand, Dagmar; Münz, Tobias; Liebe, Theresa; Heller, Regine; Henke, Andreas; Stauber, Roland H.; Reichardt, Werner; Schmid, Johannes A.; Kubatzky, Katharina F.; Heinzel, Thorsten & Krämer, Oliver H.
  
• (2012) Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte. 1: 203-214
  Habegger, Kirk M.; Matzke, Daniela; Ottaway, Nickki; Hembree, Jazzminn; Holland, Jenna; Raver, Christine; Mansfeld, Johannes; Müller, Timo D.; Perez-Tilve, Diego; Pfluger, Paul T.; Lee, Sang Jun; Diaz-Meco, Maria; Moscat, Jorge; Leitges, Michael; Tschöp, Matthias H. & Hofmann, Susanna M.
  
• (2013) A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nat Genet. 45: 1399-1404
  Leipold, Enrico; Liebmann, Lutz; Korenke, G Christoph; Heinrich, Theresa; Gießelmann, Sebastian; Baets, Jonathan; Ebbinghaus, Matthias; Goral, R Oliver; Stödberg, Tommy; Hennings, J Christopher; Bergmann, Markus; Altmüller, Janine; Thiele, Holger; Wetzel, Andrea; Nürnberg, Peter; Timmerman, Vincent; De Jonghe, Peter; Blum, Robert; Schaible, Hans-Georg; ... & Kurth, Ingo
  
• (2013) High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation. 128: 2364-2371
  Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M.; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T.; Krishna, Radhakrishna; Gordon, Scott M.; Silva, R.A. Gangani D.; Luquet, Serge; ... & Hofmann, Susanna M.
  
• (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci. 16: 426-433
  Schulz, Alexander; Baader, Stephan L; Niwa-Kawakita, Michiko; Jung, Marie Juliane; Bauer, Reinhard; Garcia, Cynthia; Zoch, Ansgar; Schacke, Stephan; Hagel, Christian; Mautner, Victor-Felix; Hanemann, C Oliver; Dun, Xin-Peng; Parkinson, David B; Weis, Joachim; Schröder, J Michael; Gutmann, David H; Giovannini, Marco & Morrison, Helen
  
• (2013) MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint. J Genet Genomics. 40: 575-578
  Li, Jing; Liu, Xiaoqian; Liao, Ji; Tian, Jie; Wang, Jue; Wang, Xin; Zhang, Jiezhong & Xu, Xingzhi
  
• (2013) Phosphoinositide 3-kinaseγ mediates microglial phagocytosis via lipid kinase independent control of cAMP. Neuroscience. 233: 44-53
  Schmidt, C.; Schneble, N.; Müller, J.P.; Bauer, R.; Perino, A.; Marone, R.; Rybalkin, S.D.; Wymann, M.P.; Hirsch, E. & Wetzker, R.
  
• (2013) Regulation of Son of sevenless by the membraneactin linker protein ezrin. Proc Natl Acad Sci USA. 110: 20587-20592
  Geißler, Katja J.; Jung, M. Juliane; Riecken, Lars Björn; Sperka, Tobias; Cui, Yan; Schacke, Stephan; Merkel, Ulrike; Markwart, Robby; Rubio, Ignacio; Than, Manuel E.; Breithaupt, Constanze; Peuker, Sebastian; Seifert, Reinhard; Kaupp, Ulrich Benjamin; Herrlich, Peter & Morrison, Helen
  
• (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 9: 693-700
  Schmeisser, Kathrin; Mansfeld, Johannes; Kuhlow, Doreen; Weimer, Sandra; Priebe, Steffen; Heiland, Ines; Birringer, Marc; Groth, Marco; Segref, Alexandra; Kanfi, Yariv; Price, Nathan L; Schmeisser, Sebastian; Schuster, Stefan; Pfeiffer, Andreas F H; Guthke, Reinhard; Platzer, Matthias; Hoppe, Thorsten; Cohen, Haim Y; Zarse, Kim; ... & Ristow, Michael
  
• (2013) S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci USA. 110: 3113-3118
  Nott, Alexi; Nitarska, Justyna; Veenvliet, Jesse V.; Schacke, Stephan; Derijck, Alwin A. H. A.; Sirko, Piotr; Muchardt, Christian; Pasterkamp, R. Jeroen; Smidt, Marten P. & Riccio, Antonella
  
• (2013) Trügerische Etiketten für Signalproteine. BIOspektrum. 19: 401-404
  Schmidt, Caroline; Schneble, Nadine; Bauer, Reinhard & Wetzker, Reinhard
  
• (2014) p53-dependent and p53- independent anticancer effects of different histone deacetylase inhibitors. Br J Cancer. 110: 656-667
  Sonnemann, J.; Marx, C.; Becker, S.; Wittig, S.; Palani, C. D.; Krämer, O. H. & Beck, J. F.
  
• (2014) Characterization of coxsackievirus B3 replication in human umbilical vein endothelial cells. Med Microbiol Immunol. 203: 217-229
  Kühnl, A.; Rien, C.; Spengler, K.; Kryeziu, N.; Sauerbrei, A.; Heller, R. & Henke, A.
  
• (2014) D-Glucosamine supplementation extends lifespan of nematodes and of aging mice. Nat Commun. 5: 3563
  Weimer, Sandra; Priebs, Josephine; Kuhlow, Doreen; Groth, Marco; Priebe, Steffen; Mansfeld, Johannes; Merry, Troy L.; Dubuis, Sébastien; Laube, Beate; Pfeiffer, Andreas F.; Schulz, Tim J.; Guthke, Reinhard; Platzer, Matthias; Zamboni, Nicola; Zarse, Kim & Ristow, Michael
  
• (2014) Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling. Dev Comp Immunol. 45: 177-189
  Skjesol, Astrid; Liebe, Theresa; Iliev, Dimitar B.; Thomassen, Ernst I.S.; Tollersrud, Linn Greiner; Sobhkhez, Mehrdad; Lindenskov Joensen, Lisbeth; Secombes, Christopher J. & Jørgensen, Jorunn B.
  
• (2014) Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab. 19: 642-52
  Segref, Alexandra; Kevei, Éva; Pokrzywa, Wojciech; Schmeisser, Kathrin; Mansfeld, Johannes; Livnat-Levanon, Nurit; Ensenauer, Regina; Glickman, Michael H.; Ristow, Michael & Hoppe, Thorsten
  
• (2014) Phosphoinositide 3-kinaseγ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells. Neuromolecular Med. 16: 704-713
  Frister, Adrian; Schmidt, Caroline; Schneble, Nadine; Brodhun, Michael; Gonnert, Falk A.; Bauer, Michael; Hirsch, Emilio; Müller, Jörg P.; Wetzker, Reinhard & Bauer, Reinhard
  
• (2014) Reversible inactivation of CO dehydrogenase with thiol compounds. Biochem Biophys Res Commun. 447: 413-418
  Kreß, Oliver; Gnida, Manuel; Pelzmann, Astrid M.; Marx, Christian; Meyer-Klaucke, Wolfram & Meyer, Ortwin
  
• (2014) Survivin and YM155: how faithful is the liaison? Biochim Biophys Acta. 1845: 202-220
  Rauch, Anke; Hennig, Dorle; Schäfer, Claudia; Wirth, Matthias; Marx, Christian; Heinzel, Thorsten; Schneider, Günter & Krämer, Oliver H.
  
• (2014) The fifth dimension of innate immunity. J Cell Commun Signal. 8: 363- 367
  Schmidt, C.; Schneble, N. & Wetzker, R.
  
• (2015) Aurora B- dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis. Sci Rep. 5: 8360
  Tian, Jie; Tian, Chuan; Ding, Yuehe; Li, Zhe; Geng, Qizhi; Xiahou, Zhikai; Wang, Jue; Hou, Wenya; Liao, Ji; Dong, Meng-Qiu; Xu, Xingzhi & Li, Jing
  
• (2015) Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nat Commun. 6: 10043
  Mansfeld, Johannes; Urban, Nadine; Priebe, Steffen; Groth, Marco; Frahm, Christiane; Hartmann, Nils; Gebauer, Juliane; Ravichandran, Meenakshi; Dommaschk, Anne; Schmeisser, Sebastian; Kuhlow, Doreen; Monajembashi, Shamci; Bremer-Streck, Sibylle; Hemmerich, Peter; Kiehntopf, Michael; Zamboni, Nicola; Englert, Christoph; Guthke, Reinhard; Kaleta, Christoph; ... & Ristow, Michael
  
• (2015) Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy. Proc Natl Acad Sci USA. 112: 5479-5484
  Matthews, Laura C.; Berry, Andrew A.; Morgan, David J.; Poolman, Toryn M.; Bauer, Kerstin; Kramer, Frederike; Spiller, David G.; Richardson, Rachel V.; Chapman, Karen E.; Farrow, Stuart N.; Norman, Michael R.; Williamson, Andrew J. K.; Whetton, Anthony D.; Taylor, Stephen S.; Tuckermann, Jan P.; White, Michael R. H. & Ray, David W.
  
• (2015) Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Res. 43: 5936-5947
  Peng, Bin; Wang, Jing; Hu, Yuan; Zhao, Hongli; Hou, Wenya; Zhao, Hongchang; Wang, Hailong; Liao, Ji & Xu, Xingzhi
  
• (2015) PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol Med. 7: 1350-65
  Deschoemaeker, Sofie; Di Conza, Giusy; Lilla, Sergio; Martín‐Pérez, Rosa; Mennerich, Daniela; Boon, Lise; Hendrikx, Stefanie; Maddocks, Oliver DK; Marx, Christian; Radhakrishnan, Praveen; Prenen, Hans; Schneider, Martin; Myllyharju, Johanna; Kietzmann, Thomas; Vousden, Karen H; Zanivan, Sara & Mazzone, Massimiliano
  
• (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 522: 354-358
  Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K.; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor; Koch, Nicole; Mauthe, Mario; Katona, Istvan; Qualmann, Britta; Weis, Joachim; Reggiori, Fulvio; Kurth, Ingo; Hübner, Christian A. & Dikic, Ivan
  
• (2015) RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status. Eur J Cancer 51: 841-851
  Sonnemann, Jürgen; Grauel, Désirée; Blümel, Lisa; Hentschel, Julia; Marx, Christian; Blumrich, Annelie; Focke, Katharina; Becker, Sabine; Wittig, Susan; Schinkel, Sandra; Krämer, Oliver H. & Beck, James F.
  
• (2015) The actin nucleator Cobl is controlled by calcium and Calmodulin. PLoS Biol. 13: e1002233
  Hou, Wenya; Izadi, Maryam; Nemitz, Sabine; Haag, Natja; Kessels, Michael M. & Qualmann, Britta
  
• (2016) Phosphoinositide 3-kinase γ restrains neurotoxic effects of microglia after focal brain ischemia. Mol Neurobiol. 53: 5468-79
  Schmidt, Caroline; Frahm, Christiane; Schneble, Nadine; Müller, Jörg P.; Brodhun, Michael; Franco, Irene; Witte, Otto W.; Hirsch, Emilio; Wetzker, Reinhard & Bauer, Reinhard
  
• (2016) Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247. Proc Natl Acad Sci U S A. 113: 10157-62
  Shabab, Mohammed; Arnold, Markus F. F.; Penterman, Jon; Wommack, Andrew J.; Bocker, Hartmut T.; Price, Paul A.; Griffitts, Joel S.; Nolan, Elizabeth M. & Walker, Graham C.
  
• (2016) Nonlinear structured illumination using a fluorescent protein activating at the readout wavelength. PLoS One. 11: e0165148
  Lu-Walther, Hui-Wen; Hou, Wenya; Kielhorn, Martin; Arai, Yoshiyuki; Nagai, Takeharu; Kessels, Michael M.; Qualmann, Britta & Heintzmann, Rainer
  
• (2016) Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase γ. Immunol Lett. 180: 9-16
  Kresinsky, Anne; Schneble, Nadine; Schmidt, Caroline; Frister, Adrian; Bauer, Reinhard; Wetzker, Reinhard & Müller, Jörg P.
  
• (2016) The DNA damage response molecule MCPH1 in brain development and beyond. Acta Biochim Biophys Sin (Shanghai). 48: 678-85
  Liu, Xiaoqian; Zhou, Zhong-Wei & Wang, Zhao-Qi
  
• (2016) The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions. Mol Biol Cell. 27: 3926- 3936
  Gottlieb-Abraham, Efrat; Gutman, Orit; Pai, Govind M.; Rubio, Ignacio & Henis, Yoav I.
  
• (2016) TSC loss distorts DNA replication programme and sensitizes cells to genotoxic stress. Oncotarget. 7: 85365-85380
  Pai, Govind M.; Zielinski, Alexandra; Koalick, Dennis; Ludwig, Kristin; Wang, Zhao-Qi; Borgmann, Kerstin; Pospiech, Helmut & Rubio, Ignacio
  
• (2016) TSC loss distorts DNA replication programme and sensitizes cells to genotoxic stress. Oncotarget. 7: 85365-85380
  Pai, Govind M.; Zielinski, Alexandra; Koalick, Dennis; Ludwig, Kristin; Wang, Zhao-Qi; Borgmann, Kerstin; Pospiech, Helmut & Rubio, Ignacio
  
• (2017) Assessment of HDACi-Induced Cytotoxicity. Methods Mol Biol. 1510: 23-45
  Marx-Blümel, Lisa; Marx, Christian; Kühne, Marie & Sonnemann, Jürgen
  
• (2017) Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination. Elife. 6: e29854
  Seemann, Eric; Sun, Minxuan; Krueger, Sarah; Tröger, Jessica; Hou, Wenya; Haag, Natja; Schüler, Susann; Westermann, Martin; Huebner, Christian A; Romeike, Bernd; Kessels, Michael M & Qualmann, Britta
  
• (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem J. 474: 983-1001
  Zibrova, Darya; Vandermoere, Franck; Göransson, Olga; Peggie, Mark; Mariño, Karina V.; Knierim, Anne; Spengler, Katrin; Weigert, Cora; Viollet, Benoit; Morrice, Nicholas A.; Sakamoto, Kei & Heller, Regine
  
• (2017) Hormesis and defense of infectious disease. Int J Mol Sci. 18: 1273
  Weis, Sebastian; Rubio, Ignacio; Ludwig, Kristin; Weigel, Cynthia & Jentho, Elisa
  
• (2017) Hormesis and defense of infectious disease. Int J Mol Sci. 18: 1273
  Weis, Sebastian; Rubio, Ignacio; Ludwig, Kristin; Weigel, Cynthia & Jentho, Elisa
  
• (2017) Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility. Mol Cell Neurosci. 78: 1-8
  Schneble, Nadine; Schmidt, Caroline; Bauer, Reinhard; Müller, Jörg P.; Monajembashi, Shamci & Wetzker, Reinhard
  
• (2017) The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J. 36: 3666-3681
  Liu, Xiaoqian; Zong, Wen; Li, Tangliang; Wang, Yujun; Xu, Xingzhi; Zhou, Zhong‐Wei & Wang, Zhao‐Qi
  
• The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factordependent cell death in a p53 null Ewing's sarcoma cell line. Invest New Drugs. 36: 396-406
  Marx, Christian; Marx-Blümel, Lisa; Lindig, Nora; Thierbach, René; Hoelzer, Doerte; Becker, Sabine; Wittig, Susan; Lehmann, Roland; Slevogt, Hortense; Heinzel, Thorsten; Wang, Zhao-Qi; Beck, James F. & Sonnemann, Jürgen
  
• (2018) Arginine methylation by PRMT2 controls the functions of the actin nucleator Cobl. Dev Cell. 45: 262-275.e8
  Hou, Wenya; Nemitz, Sabine; Schopper, Simone; Nielsen, Michael Lund; Kessels, Michael Manfred & Qualmann, Britta
  
• (2018) Direct effects of Ca2+/calmodulin on actin filament formation. Biochem Biophys Res Commun. 506: 355-360
  Izadi, Maryam; Hou, Wenya; Qualmann, Britta & Kessels, Michael M.
  
• (2018) Epigenetics: Important aspects for anesthesiologists, pain and intensive care physicians. Anaesthesist. 67: 246-254
  Reinhold, A.-K.; Jentho, E.; Schäfer, S. T.; Bauer, M. & Rittner, H. L.
  
• (2018) Potential influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts. Med Microbiol Immunol. 207: 227-242
  Zilch, Anika; Rien, Christian; Weigel, Cynthia; Huskobla, Stefanie; Glück, Brigitte; Spengler, Katrin; Sauerbrei, Andreas; Heller, Regine; Gräler, Markus & Henke, Andreas
  
• (2019) Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation. J Exp Med. 216: 152-75
  Chen, Zhiyang; Amro, Elias Moris; Becker, Friedrich; Hölzer, Martin; Rasa, Seyed Mohammad Mahdi; Njeru, Sospeter Ngoci; Han, Bing; Di Sanzo, Simone; Chen, Yulin; Tang, Duozhuang; Tao, Si; Haenold, Ronny; Groth, Marco; Romanov, Vasily S.; Kirkpatrick, Joanna M.; Kraus, Johann M.; Kestler, Hans A.; Marz, Manja; Ori, Alessandro; ... & Rudolph, K. Lenhard
  
• (2019) Modulation of K+ channel N- type inactivation by sulfhydration through hydrogen sulfide and polysulfides. Pflugers Arch. 471: 557-571
  Yang, Kefan; Coburger, Ina; Langner, Johanna M.; Peter, Nicole; Hoshi, Toshinori; Schönherr, Roland & Heinemann, Stefan H.
  
• (2019) The Na+/H+ exchanger Nhe1 modulates network excitability via GABA release. Cereb Cortex. 29: 4263-4276
  Bocker, Hartmut T.; Heinrich, Theresa; Liebmann, Lutz; Hennings, J. Christopher; Seemann, Eric; Gerth, Melanie; Jakovčevski, Igor; Preobraschenski, Julia; Kessels, Michael M.; Westermann, Martin; Isbrandt, Dirk; Jahn, Reinhard; Qualmann, Britta & Hübner,
  
• (2019) The Na+/H+ exchanger Nhe1 modulates network excitability via GABA release. Cereb Cortex. 29: 4263-4276
  Bocker, Hartmut T.; Heinrich, Theresa; Liebmann, Lutz; Hennings, J. Christopher; Seemann, Eric; Gerth, Melanie; Jakovčevski, Igor; Preobraschenski, Julia; Kessels, Michael M.; Westermann, Martin; Isbrandt, Dirk; Jahn, Reinhard; Qualmann, Britta & Hübner,
  
• (2018) DNA-Damage-Induced Hormetic Responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Mägdefrau, Ann-Sophie; Ludwig, Kristin; Weigel, Cynthia; Köse, Nilay; Guerra, Gabriela Maria; Dakhovnik, Alexander & Kosan, Christian
  
• (2018) DNA-Damage-Induced Hormetic Responses. Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Mägdefrau, Ann-Sophie; Ludwig, Kristin; Weigel, Cynthia; Köse, Nilay; Guerra, Gabriela Maria; Dakhovnik, Alexander & Kosan, Christian
  
• (2018) DNA-Damage-Induced Hormetic Responses. Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Mägdefrau, Ann-Sophie; Ludwig, Kristin; Weigel, Cynthia; Köse, Nilay; Guerra, Gabriela Maria; Dakhovnik, Alexander & Kosan, Christian
  
• (2018) Metabolic stress - signaling and metabolic adaptation, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Balakrishnan, Preetha; Liebe, Theresa; Amro, Elias; Dhaka, Lajwanti; Heinzel, Thorsten & Heller, Regine
  
• (2018) Metabolic stress - signaling and metabolic adaptation, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Balakrishnan, Preetha; Liebe, Theresa; Amro, Elias; Dhaka, Lajwanti; Heinzel, Thorsten & Heller, Regine
  
• (2018) Metabolic stress - signaling and metabolic adaptation, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Balakrishnan, Preetha; Liebe, Theresa; Amro, Elias; Dhaka, Lajwanti; Heinzel, Thorsten & Heller, Regine
  
• (2018) Neuronal Stress and Its Hormetic Aspects, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Hofbrucker-MacKenzie, Sarah Ann; Sivaprakasam, Iswariya; Ji, Yuanyuan; Kessels, Michael Manfred & Qualmann, Britta
  
• (2018) Pathogen-induced hormetic responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Jentho, Elisa; Lajqi, Trim; Yang, Kefan; Winkler, René; Stojiljkovic, Milan; Wetzker, Reinhard & Bauer, Michael
  
• (2018) Pathogen-induced hormetic responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Jentho, Elisa; Lajqi, Trim; Yang, Kefan; Winkler, René; Stojiljkovic, Milan; Wetzker, Reinhard & Bauer, Michael
  
• (2018) Pathogen-induced hormetic responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
  Jentho, Elisa; Lajqi, Trim; Yang, Kefan; Winkler, René; Stojiljkovic, Milan; Wetzker, Reinhard & Bauer, Michael
  
• (2019) Age effect on thyroid hormone brain response in male mice. Endocrine. 66: 596-606
  Kerp, Helena; Engels, Kathrin; Kramer, Frederike; Doycheva, Denica; Sebastian Hönes, Georg; Zwanziger, Denise; Christian Moeller, Lars; Heuer, Heike & Führer, Dagmar
  
• (2019) Azithromycin does not improve disease severity in acute experimental pancreatitis. PLoS One. 14: e0216614
  Weis, Sebastian; Heindl, Mario; Carvalho, Tania; Jentho, Elisa; Lorenz, Jana; Sommerer, Ines; Mössner, Joachim & Hoffmeister, Albrecht
  
• (2019) Heme Induces Innate Immune Memory. BioRxiv
  Jentho, Elisa; Novakovic, Boris; Ruiz-Moreno, Cristian; Kourtzelis, Ioannis; Martins, Rui; Chavakis, Triantafyllos; Soares, Miguel Perreira; Kalafati, Lydia; Guerra, Joel; Roestel, Franziska; Bohm, Peter; Godmann, Maren; Grinenko, Tatyana; Eugster, Anne; Beretta, Martina; Joosten, Leo A.B.; Netea, Mihai G.; Stunnenberg, Hendrik G.; Bauer, Michael; ... & Weis, Sebastian
  
• (2019) Memory-like inflammatory responses of microglia to rising doses of LPS: Key role of PI3Kγ. Front Immunol. 10: 2492
  Lajqi, Trim; Lang, Guang-Ping; Haas, Fabienne; Williams, David L.; Hudalla, Hannes; Bauer, Michael; Groth, Marco; Wetzker, Reinhard & Bauer, Reinhard
  
• (2019) Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Res Cardiol. 114: 26
  Ndongson-Dongmo, Bernadin; Lang, Guang-Ping; Mece, Odeta; Hechaichi, Nadine; Lajqi, Trim; Hoyer, Dirk; Brodhun, Michael; Heller, Regine; Wetzker, Reinhard; Franz, Marcus; Levy, Finn Olav & Bauer, Reinhard
  
• (2019) The enigmatic function of PARP1: From PARylation activity to PAR readers. Cells. 8: 1625
  Kamaletdinova, Tatiana; Fanaei-Kahrani, Zahra & Wang, Zhao-Qi
  
• (2019) The enigmatic function of PARP1: From PARylation activity to PAR readers. Cells. 8: 1625
  Kamaletdinova, Tatiana; Fanaei-Kahrani, Zahra & Wang, Zhao-Qi
  
• (2019) Toxin-induced hormesis may restrain aging. Biogerontology. 20: 571-581
  Lajqi, Trim; Stojiljkovic, Milan & Wetzker, Reinhard
  
• (2020) Impact of ambient temperature on inflammation-induced encephalopathy in endotoxemic mice-role of phosphoinositide 3-kinase gamma. J Neuroinflammation. 17: 292
  Lang, Guang-Ping; Ndongson-Dongmo, Bernadin; Lajqi, Trim; Brodhun, Michael; Han, Yingying; Wetzker, Reinhard; Frasch, Martin G. & Bauer, Reinhard
  
• (2020) Impact of intracellular hemin on N-type inactivation of voltage-gated K+ channels. Pflugers Arch. 472: 551-560
  Coburger, Ina; Yang, Kefan; Bernert, Alisa; Wiesel, Eric; Sahoo, Nirakar; Swain, Sandip M.; Hoshi, Toshinori; Schönherr, Roland & Heinemann, Stefan H.
  
• (2020) Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans. Nat Metab. 2: 1316-1331
  Espada, Lilia; Dakhovnik, Alexander; Chaudhari, Prerana; Martirosyan, Asya; Miek, Laura; Poliezhaieva, Tetiana; Schaub, Yvonne; Nair, Ashish; Döring, Nadia; Rahnis, Norman; Werz, Oliver; Koeberle, Andreas; Kirkpatrick, Joanna; Ori, Alessandro & Ermolaeva, Maria A.
  
• (2020) Memory-like responses of brain microglia are controlled by developmental state and pathogen dose. Front Immunol. 11: 54641
  Lajqi, Trim; Stojiljkovic, Milan; Williams, David L.; Hudalla, Hannes; Bauer, Michael; Witte, Otto W.; Wetzker, Reinhard; Bauer, Reinhard & Schmeer, Christian
  
• (2020) mTORC1 is not principally involved in the induction of human endotoxin tolerance. Front Immunol. 11: 1515
  Ludwig, Kristin; Husain, Ralf A. & Rubio, Ignacio
  
• (2020) Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495. Biochem J. 477: 3453-3469
  Spengler, Katrin; Zibrova, Darya; Woods, Angela; Langendorf, Christopher G.; Scott, John W.; Carling, David & Heller, Regine
  
• (2020) S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis. EBioMedicine. 58: 102898
  Weigel, Cynthia; Hüttner, Sören S.; Ludwig, Kristin; Krieg, Nadine; Hofmann, Susann; Schröder, Nathalie H.; Robbe, Linda; Kluge, Stefan; Nierhaus, Axel; Winkler, Martin S.; Rubio, Ignacio; von Maltzahn, Julia; Spiegel, Sarah & Gräler, Markus H.
  
• (2020) The peroxisome proliferator-activated receptor (PPAR)-γ antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) triggers perilipin 2 expression via PPARδ and induces lipogenesis and triglyceride accumulation in human THP-1 macrophages. Mol Pharmacol. 97: 212-225
  Schubert, Martin; Becher, Stefanie; Wallert, Maria; Maeß, Marten B.; Abhari, Masoumeh; Rennert, Knut; Mosig, Alexander S.; Große, Silke; Heller, Regine; Grün, Michael & Lorkowski, Stefan
  
• (2020) VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1. Cells. 9: 687
  Spengler, Katrin; Kryeziu, Nderim; Große, Silke; Mosig, Alexander S. & Heller, Regine
  
• (2020) Validation of a monoclonal antibody directed against the human sphingosine 1-phosphate receptor type 1. J Immunol Methods. 30: 112953
  Thuy, Andreas V.; Jeya Paul, Jefri; Weigel, Cynthia; Ziegler, Anke C.; Guntinas-Lichius, Orlando & Gräler, Markus H.
  
• (2021) Barrier maintenance by S1P during inflammation and sepsis. Tissue Barriers. Jun 21:1940069
  Ziegler, Anke C. & Gräler, Markus H.
  
• (2021) Cell type-specific role of RNA nuclease SMG6 in neurogenesis. Cells. 10: 3365
  Guerra, Gabriela Maria; May, Doreen; Kroll, Torsten; Koch, Philipp; Groth, Marco; Wang, Zhao-Qi; Li, Tang-Liang & Grigaravičius, Paulius
  
• (2021) Lysine methyltransferase G9a is an important modulator of trained immunity. Clin Transl Immunology. 10: e1253
  Mourits, Vera P; van Puffelen, Jelmer H; Novakovic, Boris; Bruno, Mariolina; Ferreira, Anaísa V; Arts, Rob JW; Groh, Laszlo; Crișan, Tania O; Zwaag, Jelle; Jentho, Elisa; Kox, Matthijs; Pickkers, Peter; van de Veerdonk, Frank L; Weis, Sebastian; Oosterwijk, Egbert; Vermeulen, Sita H; Netea, Mihai G & Joosten, Leo AB
  
• (2021) Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation. Nat Commun. 12: 6743
  Di Sanzo, Simone; Spengler, Katrin; Leheis, Anja; Kirkpatrick, Joanna M.; Rändler, Theresa L.; Baldensperger, Tim; Dau, Therese; Henning, Christian; Parca, Luca; Marx, Christian; Wang, Zhao-Qi; Glomb, Marcus A.; Ori, Alessandro & Heller, Regine
  
• (2021) Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation. Nat Commun. 12: 6743
  Di Sanzo, Simone; Spengler, Katrin; Leheis, Anja; Kirkpatrick, Joanna M.; Rändler, Theresa L.; Baldensperger, Tim; Dau, Therese; Henning, Christian; Parca, Luca; Marx, Christian; Wang, Zhao-Qi; Glomb, Marcus A.; Ori, Alessandro & Heller, Regine
  
• (2021) Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells. Mol Oncol. 5: 3404-3429
  Marx, Christian; Sonnemann, Jürgen; Beyer, Mandy; Maddocks, Oliver D. K.; Lilla, Sergio; Hauzenberger, Irene; Piée‐Staffa, Andrea; Siniuk, Kanstantsin; Nunna, Suneetha; Marx‐Blümel, Lisa; Westermann, Martin; Wagner, Tobias; Meyer, Felix B.; Thierbach, René; Mullins, Christina S.; Kdimati, Said; Linnebacher, Michael; Neri, Francesco; Heinzel, Thorsten; ... & Krämer, Oliver H.
  
• (2021) PI3Kgamma mediates microglial proliferation and cell viability via ROS. Cells. 10: 2534
  Schmidt, Caroline; Schneble-Löhnert, Nadine; Lajqi, Trim; Wetzker, Reinhard; Müller, Jörg P. & Bauer, Reinhard
  
• (2021) PI3Kgamma mediates microglial proliferation and cell viability via ROS. Cells. 10: 2534
  Schmidt, Caroline; Schneble-Löhnert, Nadine; Lajqi, Trim; Wetzker, Reinhard; Müller, Jörg P. & Bauer, Reinhard
  
• (2021) Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response. EMBO Rep. 22: e52905
  Gutiérrez‐Gutiérrez, Óscar; Felix, Daniel A; Salvetti, Alessandra; Amro, Elias M; Thems, Anne; Pietsch, Stefan; Koeberle, Andreas; Rudolph, K Lenhard & González‐Estévez, Cristina
  
• (2021) Sphingosine 1-phosphate in sepsis and beyond: Its role in Disease toleranceand host defense and the impact of carrier molecules. Cell Signal. 78: 109849
  Ziegler, Anke C.; Müller, Tina & Gräler, Markus H.
  
• (2021) The role of the pathogen dose and PI3Kγ in immunometabolic reprogramming of microglia for innate immune memory. Int J Mol Sci. 22: 2578
  Lajqi, Trim; Marx, Christian; Hudalla, Hannes; Haas, Fabienne; Große, Silke; Wang, Zhao-Qi; Heller, Regine; Bauer, Michael; Wetzker, Reinhard & Bauer, Reinhard
  
• (2021) The role of the pathogen dose and PI3Kγ in immunometabolic reprogramming of microglia for innate immune memory. Int J Mol Sci. 22: 2578
  Lajqi, Trim; Marx, Christian; Hudalla, Hannes; Haas, Fabienne; Große, Silke; Wang, Zhao-Qi; Heller, Regine; Bauer, Michael; Wetzker, Reinhard & Bauer, Reinhard
  
• (2021) Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme. Proc Natl Acad Sci U S A. 118: e2102698118
  Jentho, Elisa; Ruiz-Moreno, Cristian; Novakovic, Boris; Kourtzelis, Ioannis; Megchelenbrink, Wout. L.; Martins, Rui; Chavakis, Triantafyllos; Soares, Miguel P.; Kalafati, Lydia; Guerra, Joel; Roestel, Franziska; Bohm, Peter; Godmann, Maren; Grinenko, Tatyana; Eugster, Anne; Beretta, Martina; Joosten, Leo A. B.; Netea, Mihai G.; Bauer, Michael; ... & Weis, Sebastian