Epigenome regulation by ATP-dependent nucleosome remodelers (A01)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 109546710

The ATP-dependent nucleosome remodeler CHD4/Mi-2 plays pivotal roles in normal differentiation and malignancy. In the past funding period we have unraveled molecular mechanisms that direct CHD4/dMi-2 to its sites of action on chromatin. We will build on these insights to uncover the effects of CHD4/Mi-2 mutations identified in cancer and neurodevelopmental disorders on CHD4/Mi-2 remodeling activity and the epigenome. In addition, we will investigate different approaches to modulate CHD4/Mi-2 activity by small molecules and peptides with the long term goal to ameliorate the consequences of defective nucleosome remodeling in disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 81: Chromatin Changes in Differentiation and Malignancies
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professor Dr. Alexander Brehm