Modulation of sodium/proton exchanger activity by covalent modification and protein interaction (P21)

• Subject Area: Structural Biology
• Term: from 2011 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

Sodium/proton exchangers are key players in the essential control of intracellular pH and cell volume. The precise modulation of their transport activity is the prerequisite for their distinct functions in a broad spectrum of physiological processes. Their dysfunction is implicated in several diseases including epilepsy, cardiac hypertrophy and cancer. We aim for the elucidation of mechanism and structural basis of sodium/proton exchange activity modulated by the interaction with regulatory proteins and covalent modification with emphasis on the link to Ca2+ signaling to contribute to a detailed understanding of the specific functions of sodium/proton exchangers in health and disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Carola Hunte