EXC 1010:  Cluster für Systemneurologie - München

• Fachliche Zuordnung: Neurowissenschaften
• Förderung: Förderung von 2012 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 194407705

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

SyNergy definiert Systemneurologie als einen neuen Forschungsansatz, bei dem Systembiologie und Systemische Neurowissenschaften mit klinischer Neurologie verbunden werden, um integrativ zu verstehen, wie neurologische Erkrankungen aus der Interaktion degenerativer, immunologischer und vaskulärer Mechanismen entstehen. Highlights während der Förderperiode: ● hat SyNergy krankheitsübergreifende Tandem-Projekte initiiert, deren Erfolg sich in >230 Veröffentlichungen in Journalen mit einem Impact-Faktor >10 und einem 80%igen Anstieg gemeinsamer Publikationen von Clusterwissenschaftlern der LMU und TUM zeigt; ● wurden durch SyNergy aufstrebende Spitzenforscher/innen berufen, um Lücken im Forschungsspektrum zu füllen und das Team von Cluster-Wissenschaftlern (darunter 13 mit ERC-Förderung) mit zusätzlicher Expertise in der Systemneurologie zu verstärken; ● hat SyNergy entscheidend zur Einrichtung eines Zentrums für Schlaganfall- und Demenzforschung (CSD) beigetragen, in dem Forschung und Klinik integriert sind, und 10 SyNergy-Arbeitsgruppen beider Universitäten beherbergt werden; ● hat SyNergy ein Programm für forschende Ärzte geschaffen, unter dessen Absolventen zwei eine DFG Emmy-Noether-Gruppe eingeworben haben und nun SyNergy-PIs sind; ● hat SyNergy neue Programme zur Ausbildung von Nachwuchswissenschaftler/innen von Gymnasiasten bis hin zu Postdoktoranden etabliert und Chancengleichheit durch eine Karriereberatung und Unterstützung von Familien und Eltern gefördert.

Link zum Abschlussbericht

https://dx.doi.org/10.2314/KXP:1698240678

Projektbezogene Publikationen (Auswahl)

• A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol. 2013 Mar 10
  Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG
  
• Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016 Jun 13
  Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M
  
• Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nat Commun. 2013 Jul 10;4:2125
  Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M
  
• Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes. Nat Protoc. 8(3):481-90 (2013)
  Romanelli E, Sorbara CD, Nikić I, Dagkalis A, Misgeld T, Kerschensteiner M
  
• EphrinB3/EphA4-Mediated Guidance of Ascending and Descending Spinal Tracts. Neuron. 2013 Dec 18;80(6):1407-20
  Paixão S, Balijepalli A, Serradj N, Niu J, Luo W, Martin JH, Klein R
  
• Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. Ann Neurol. 73(1):86-94 (2013)
  Buck D, Albrecht E, Aslam M, Goris A, Hauenstein N, Jochim A; International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium, Cepok S, Grummel V, Dubois B, Berthele A, Lichtner P, Gieger C, Winkelmann J, Hemmer B
  
• Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci. 2013 Mar 31
  Bardehle S, Krüger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M
  
• Making waves: initiation and propagation of corticothalamic ca(2+) waves in vivo. Neuron. 2013 Mar 20;77(6):1136-50
  Stroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A
  
• Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol. 2013 May;12(5):483-97
  Wardlaw JM, Smith C, Dichgans M
  
• Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog glia. Cell Stem Cell. 2013 Apr 4;12(4):426-39
  Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M
  
• Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature. 2013 May 22
  Hondele M, Stuwe T, Hassler M, Halbach F, Bowman A, Zhang ET, Nijmeijer B, Kotthoff C, Rybin V, Amlacher S, Hurt E, Ladurner AG
  
• The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network. Cell Stem Cell. 2013 Aug 6
  Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M
  
• The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS. Science (2013) Feb 7
  Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D
  
• The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO. Molecular cell
  Mueller-Rischart A-K, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn P-H, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Truembach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF
  
• Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat Neurosci. 2013 Sep 1
  Viganò F, Möbius W, Götz M, Dimou L
  
• Trnp1 regulates expansion and folding of the Mammalian cerebral cortex by control of radial glial fate. Cell. 2013 Apr 25;153(3):535-49
  Stahl R, Walcher T, De Juan Romero C, Pilz GA, Cappello S, Irmler M, Sanz-Aquela JM, Beckers J, Blum R, Borrell V, Götz M
  
• A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nat Commun. 2014 Dec 16;5:5683
  Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M, Misgeld T
  
• An assay to image neuronal microtubule dynamics in mice. Nat Commun. 2014 Sep 12;5:4827
  Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T
  
• Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014 Apr 29
  Schirmer L, Srivastava R, Kalluri SR, Böttinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, Hemmer B
  
• FLRT Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development. Neuron. 2014 Oct 22;84(2):370-85
  Seiradake E, Del Toro D, Nagel D, Cop F, Härtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R
  
• IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4(+) T cells by inducing Blimp1. Nat Commun. 2014 May 6;5:3770
  Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T
  
• In Vivo Targeting of Adult Neural Stem Cells in the Dentate Gyrus by a Split-Cre Approach. Stem Cell Reports. 2014 Feb 6;2(2):153-62
  Beckervordersandforth R, Deshpande A, Schäffner I, Huttner HB, Lepier A, Lie DC, Götz M
  
• Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1. Cell. 2014 Feb 27;156(5):975-85
  Raychaudhuri S, Loew C, Körner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU
  
• Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat Med. 2014 Apr 20
  Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T
  
• NMDA Receptor-Dependent Multidendrite Ca2+ Spikes Required for Hippocampal Burst Firing In Vivo. Neuron. 2014 Feb 18. pii: S0896-6273
  Grienberger C, Chen X, Konnerth A
  
• Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nat Commun. 2014 May 28;5:3915
  Neuner J, Ovsepian SV, Dorostkar M, Filser S, Gupta A, Michalakis S, Biel M, Herms J
  
• Pervasive Axonal Transport Deficits in Multiple Sclerosis Models. Neuron. 2014 Nov 25
  Sorbara CD, Wagner NE, Ladwig A, Nikić I, Merkler D, Kleele T, Marinković P, Naumann R, Godinho L, Bareyre FM, Bishop D, Misgeld T, Kerschensteiner M
  
• Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon. Genome Res. 2014 Mar 18
  Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J
  
• STIM1 Controls Neuronal Ca(2+) Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior. Neuron. 2014 May 7;82(3):635-44
  Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A
  
• Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome. Am J Hum Genet. 2014 Jul 3;95(1):85-95
  Schulte EC, Kousi M, Tan PL, Tilch E, Knauf F, Lichtner P, Trenkwalder C, Högl B, Frauscher B, Berger K, Fietze I, Hornyak M, Oertel WH, Bachmann CG, Zimprich A, Peters A, Gieger C, Meitinger T, Müller-Myhsok B, Katsanis N, Winkelmann J
  
• The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol. 2014 Jan 27
  Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R
  
• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014 Jul 2;6(243):243ra86
  Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C
  
• Amyloid- PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment. Mol Psychiatry. 2015 Jun 9
  Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A
  
• ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence. Mol Cell. 2015 Sep 3;59(5):713-5
  Kozlowski M, Ladurner AG
  
• Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science. 2015 Dec 3
  Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS
  
• Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models. Nat Neurosci. 2015 Nov 9
  Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, Förstl H, Konnerth A
  
• Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing. Acta Neuropathol. 2015 Jun 18
  Schludi MH, May S, Grässer FA, Rentzsch K, Kremmer E, Küpper C, Klopstock T; German Consortium for Frontotemporal Lobar Degeneration; Bavarian Brain Banking Alliance, Arzberger T, Edbauer D
  
• Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone. Nat Neurosci. 2015 Mar 2
  Calzolari F, Michel J, Baumgart EV, Theis F, Götz M, Ninkovic J
  
• Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming. Cell Stem Cell. 2015 Dec 30. pii: S1934-5909(15)00548-2
  Gascón S, Murenu E, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Robertson SP, Schroeder T, Beckers J, Irmler M, Berndt C, Angeli JP, Conrad M, Berninger B, Götz M
  
• Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET. Mol Psychiatry. 2015 Oct;20(10):1141
  Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A
  
• Neurodevelopment. Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain. Science. 2015 May 15;348(6236):789-93
  Barbosa JS, Sanchez-Gonzalez R, Di Giaimo R, Baumgart EV, Theis FJ, Götz M, Ninkovic J
  
• Pericytes are involved in the pathogenesis of CADASIL. Ann Neurol. 2015 Aug 27
  Ghosh M, Balbi M, Hellal F, Dichgans M, Lindauer U, Plesnila N
  
• Recessive Mutations in the α3 (VI) Collagen Gene COL6A3 Cause Early-Onset Isolated Dystonia. Am J Hum Genet. 2015 May 13
  Zech M, Lam DD, Francescatto L, Schormair B, Salminen AV, Jochim A, Wieland T, Lichtner P, Peters A, Gieger C, Lochmüller H, Strom TM, Haslinger B, Katsanis N, Winkelmann J
  
• Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. Brain. 2015 Dec 14
  Jürgens T, Jafari M, Kreutzfeldt M, Bahn E, Brück W, Kerschensteiner M, Merkler D
  
• Rescue of long-range circuit dysfunction in Alzheimer's disease models. Nat Neurosci. 2015 Nov;18(11):1623-30
  Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A
  
• Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia. Sci Transl Med. 2015 Aug 5;7(299):299ra121
  Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A
  
• Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes. Cell Stem Cell. 2015 Jul 2;17(1):74-88
  Masserdotti G, Gillotin S, Sutor B, Drechsel D, Irmler M, Jørgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, Guillemot F, Götz M
  
• Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 2015 May 7;161(4):919-32
  Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU
  
• η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 2015 Aug 31
  Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C
  
• Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biol Psychiatry. 2016 Dec 26
  Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J
  
• CTLA-4 as immunological checkpoint in the development of multiple sclerosis. Ann Neurol. 2016 Jun 28
  Gerdes LA, Held K, Beltran E, Berking C, Prinz JC, Junker A, Tietze JK, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K, Hohlfeld R
  
• Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proc Natl Acad Sci U S A. 2016 Jun 20
  Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K
  
• Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Sci Transl Med. 2016 Dec 14;8(369):369ra178
  Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C; Dominantly Inherited Alzheimer Network
  
• Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. J Cell Biol. 2016 Jun 27
  Gong J, Körner R, Gaitanos L, Klein R
  
• Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature. 2016 Mar 10;531(7593):191-5
  Choe YJ, Park SH, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU
  
• Haploinsufficiency of KMT2B, Encoding the Lysine-Specific Histone Methyltransferase 2B, Results in Early-Onset Generalized Dystonia. Am J Hum Genet. 2016 Nov 9
  Zech M, Boesch S, Maier EM, Borggraefe I, Vill K, Laccone F, Pilshofer V, Ceballos-Baumann A, Alhaddad B, Berutti R, Poewe W, Haack TB, Haslinger B, Strom TM, Winkelmann J
  
• In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol. 2016 Mar 6
  Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B
  
• Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration. Genes Dev. 2016 Oct 1;30(19):2199-2212
  Ramesh V, Bayam E, Cernilogar FM, Bonapace IM, Schulze M, Riemenschneider MJ, Schotta G, Götz M
  
• Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun. 2016 Nov 16;7:13275
  Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M
  
• Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease. Acta Neuropathol. 2016 Jan 2
  Zou C, Shi Y, Ohli J, Schüller U, Dorostkar MM, Herms J
  
• Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis. Brain. 2016 Aug 30
  Knier B, Schmidt P, Aly L, Buck D, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T
  
• Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nat Methods. 2016 Aug 22
  Pan C, Cai R, Quacquarelli FP, Ghasemigharagoz A, Lourbopoulos A, Matryba P, Plesnila N, Dichgans M, Hellal F, Ertürk A
  
• Soluble Oligomers of PolyQ- Expanded Huntingtin Target a Multiplicity of Key Cellular Factors. Mol Cell. 2016 Aug 25. S1097-2765(16)30375-6
  Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU
  
• TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. EMBO J. 2016 Sep 12
  Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Brüstle O, Küpper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D
  
• Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. J Cell Biol. 2016 Sep 12;214(6):735-52
  Gaitanos TN, Koerner J, Klein R
  
• Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2016 Nov 28
  Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller- Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T
  
• Transplanted embryonic neurons integrate into adult neocortical circuits. Nature. 2016 Oct 26
  Falkner S, Grade S, Dimou L, Conzelmann KK, Bonhoeffer T, Götz M, Hübener M
  
• A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene. Mol Cell. 2017 Dec 7;68(5):860-871.e7
  Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD, Ladurner AG
  
• Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017 Nov 16;68(4):786-796.e6
  Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, Behrends C
  
• BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med. 2017 Dec 6;9(419)
  Fard MK, van der Meer F, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M
  
• Central amygdala circuits modulate food consumption through a positive-valence mechanism. Nat Neurosci. 2017 Aug 21
  Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann KK, Lüthi A, Klein R
  
• Cortical pathology in MS detected by the T1/T2- weighted ratio from routine MRI. Ann Neurol. 2017 Aug 18
  Righart R, Biberacher V, Jonkman LE, Klaver R, Schmidt P, Buck D, Berthele A, Kirschke JS, Zimmer C, Hemmer B, Geurts JJ, Mühlau M
  
• Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurol. 2017 Nov;16(11):898-907
  Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, Dauvilliers Y, Stefani A, Högl B, Poewe W, Kemlink D, Sonka K, Bachmann CG, Paulus W, Trenkwalder C, Oertel WH, Hornyak M, Teder-Laving M, Metspalu A, Hadjigeorgiou GM, Polo O, Fietze I, Ross OA, Wszolek Z, Butterworth AS, Soranzo N, Ouwehand WH, Roberts DJ, Danesh J, Allen RP, Earley CJ, Ondo WG, Xiong L, Montplaisir J, Gan-Or Z, Perola M, Vodicka P, Dina C, Franke A, Tittmann L, Stewart AFR, Shah SH, Gieger C, Peters A, Rouleau GA, Berger K, Oexle K, Di Angelantonio E, Hinds DA, Müller-Myhsok B, Winkelmann J; 23andMe Research Team; DESIR study group
  
• Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules. Cell. 2017 May 4;169(4):621-635.e16
  Del Toro D, Ruff T, Cederfjäll E, Villalba A, Seyit-Bremer G, Borrell V, Klein R
  
• Seq Identifies Circulating miR-125a-5p, miR-125b-5p and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke. Circ Res. 2017 Jul 19
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• Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathol. 2017 Apr 13
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