Project Details
Projekt Print View

Rage signalling and function in lung immunity (A25)

Subject Area Immunology
Term from 2011 to 2017
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 15477770
 
In this grant application, we aim to molecularly decipher how the receptor for advanced glycation endproducts (RAGE) binds to nucleic acid ligands and interacts with itself. We will define the crystal structure of the RAGE/DNA complex and test the function of critical residues involved in binding of nucleic acids. We will further investigate how ligand binding to RAGE leads to cellular activation and influences its trafficking behavior. In a mouse respiratory syncytial virus infection model we will finally assess the physiological role of RAGE in lung antiviral responses.
DFG Programme Collaborative Research Centres
 
 

Additional Information

Textvergrößerung und Kontrastanpassung