Suppression humaner T-Zellen durch 5'-Methylthioadenosin

• Antragsteller: Dr. Michael Aigner; Professor Dr. Andreas Mackensen
• Fachliche Zuordnung: Hämatologie, Onkologie
• Förderung: Förderung von 2011 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 190230491

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

We were able to elucidate the molecular mechanism of MTA induced T cell inhibiton, identifying p53 as a key molecule. Furthermore, we were able to demonstrate that MTA induces metablic changes in T cells that resemble an un-acticated T cell phenotye, strenghtening the data that MTA inhibits T cell activaction. In addition, we could show that NK cells also were impaired in the presence of MTA, and showed a differing molecular mode of inhibition than T cells.

Projektbezogene Publikationen (Auswahl)

• (2013). IFN-gamma-driven intratumoral microenvironment exhibits superior prognostic effect compared with an IFN-alpha-driven microenvironment in patients with colon carcinoma. Am J Pathol Dec; 183(6): 1897-1909
  Grenz, Sandra; Naschberger, Elisabeth; Merkel, Susanne; Britzen-Laurent, Nathalie; Schaal, Ute; Konrad, Andreas; Aigner, Michael; Rau, Tilman T.; Hartmann, Arndt; Croner, Roland S.; Hohenberger, Werner & Stürzl, Michael
  
• (2016). LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. Cell Metab Nov 8; 24(5): 657-671
  Brand, Almut; Singer, Katrin; Koehl, Gudrun E.; Kolitzus, Marlene; Schoenhammer, Gabriele; Thiel, Annette; Matos, Carina; Bruss, Christina; Klobuch, Sebastian; Peter, Katrin; Kastenberger, Michael; Bogdan, Christian; Schleicher, Ulrike; Mackensen, Andreas; Ullrich, Evelyn; Fichtner-Feigl, Stefan; Kesselring, Rebecca; Mack, Matthias; Ritter, Uwe; ... & Kreutz, Marina
  
• (2016). Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells. Oncoimmunology Aug; 5(8): e1184802
  Henrich, Frederik C.; Singer, Katrin; Poller, Kerstin; Bernhardt, Luise; Strobl, Carolin D.; Limm, Katharina; Ritter, Axel P.; Gottfried, Eva; Völkl, Simon; Jacobs, Benedikt; Peter, Katrin; Mougiakakos, Dimitrios; Dettmer, Katja; Oefner, Peter J.; Bosserhoff, Anja-Katrin; Kreutz, Marina P.; Aigner, Michael & Mackensen, Andreas
  
• (2018). Visualizing Single-Cell Secretion Dynamics with Single-Protein Sensitivity. Nano Lett Jan 10; 18(1): 513-519
  McDonald, Matthew P.; Gemeinhardt, André; König, Katharina; Piliarik, Marek; Schaffer, Stefanie; Völkl, Simon; Aigner, Michael; Mackensen, Andreas & Sandoghdar, Vahid
  
• (2018). Clinical-grade generation of peptidestimulated CMV/EBV-specific T cells from G-CSF mobilized stem cell grafts. J Transl Med May 9; 16(1): 124
  Gary, Regina; Aigner, Michael; Moi, Stephanie; Schaffer, Stefanie; Gottmann, Anja; Maas, Stefanie; Zimmermann, Robert; Zingsem, Jürgen; Strobel, Julian; Mackensen, Andreas; Mautner, Josef; Moosmann, Andreas & Gerbitz, Armin