Hypersensitivität gegenüber sozialer Bedrohung, Ärger, und Aggression bei der Borderline Persönlichkeitsstörung
Zusammenfassung der Projektergebnisse
Within two funding periods we have identified important biological and psychological mediators of reactive aggression in borderline personality disorder (BPD). These proposed biobehavioral mechanisms could be published and have been targeted in a randomized-controlled clinical study. In particular, the results of the first funding period indicate that a heightened sensitivity for interpersonal threat related with increase early, visual but reduced structural and categorical processing, a tendency to approach rather than avoid interpersonal threats related to decreased lateral prefrontal-amygdala functional coupling, as well as deficient anger regulation related to prefrontal-amygdala imbalance could be important mechanisms for aggression in BPD. Furthermore, increased baseline testosterone and cortisol awakening responses might be endocrine correlates of aggression. Therefore, a 6-week group therapy which targets these as well as further mechanisms suggested by the literature (emotional contagion and reduced cognitive theory of mind) was tested against a non-specific supportive psychotherapy. The project has already resulted in a list of publications, several doctoral theses, and a habilitation. Further analyses are still ongoing. Importantly, the RCT has been almost completed with final follow-up measures.
Projektbezogene Publikationen (Auswahl)
- (2014). Impairments of interpersonal functioning: Empathy and intimacy in borderline personality disorder. Psychopathology, 47(4), 220-234
Jeung, H., & Herpertz, S. C.
(Siehe online unter https://doi.org/10.1159/000357191) - (2014). Social dysfunctioning and brain in borderline personality disorder. Psychopathology, 47(6), 417-424
Herpertz, S. C., Jeung, J., Mancke, F., & Bertsch, K.
(Siehe online unter https://doi.org/10.1159/000365106) - (2014). The social-cognitive basis of personality disorders. Current Opinion in Psychiatry, 27(1), 73-77
Herpertz, S. C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1097/YCO.0000000000000026) - (2015). Aggression in borderline personality disorder: A multidimensional model. Personality Disorders: Theory, Research, and Treatment, 6(3), 278-291
Mancke, F., Herpertz, S. C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1037/per0000098) - (2015). Gender differences in aggression of borderline personality disorder. Borderline Personality Disorder and Emotion Dysregulation, 2(1), 7
Mancke, F., Bertsch, K., & Herpertz, S. C.
(Siehe online unter https://doi.org/10.1186/s40479-015-0028-7) - (2016). Time course of facial emotion processing in women with borderline personality disorder: An ERP study. Journal of Psychiatry & Neuroscience: JPN, 41(1), 16-26
Hidalgo, N. A. I., Oelkers-Ax, R., Nagy, K., Mancke, F., Bohus, M., Herpertz, S. C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1503/jpn.140215) - (2017). Brain mechanisms underlying reactive aggression in borderline personality disorder - Sex matters. Biological Psychiatry, 82(4), 257-266
Herpertz, S. C., Nagy, K., Ueltzhöffer, K., Schmitt, R., Mancke, F., Schmahl, C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1016/j.biopsych.2017.02.1175) - (2017). Emotion dysregulation and trait anger sequentially mediate the association between borderline personality disorder and aggression. Journal of Personality Disorders, 31(2), 256-272
Mancke, F., Herpertz, S. C., Kleindienst, N., & Bertsch, K.
(Siehe online unter https://doi.org/10.1521/pedi_2016_30_247) - (2018). Borderline personality disorder. Nature Reviews Disease Primers, 4, 18029
Gunderson, J. G., Herpertz, S. C., Skodol, A. E., Torgersen, S., & Zanarini, M. C.
(Siehe online unter https://doi.org/10.1038/nrdp.2018.29) - (2018). Correlates of aggression in personality disorder: An update. Current Psychiatry Reports, 20(8), 53
Mancke, F., Herpertz, S. C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1007/s11920-018-0929-4) - (2018). Heightened salience of anger and aggression in female adolescents with borderline personality disorder—A script-based fMRI study. Frontiers in Behavioral Neuroscience, 12(57)
Krauch, M., Ueltzhöffer, K., Brunner, R., Kaess, M., Hensel, S., Herpertz, S. C., & Bertsch, K.
(Siehe online unter https://doi.org/10.3389/fnbeh.2018.00057) - (2018). Neural correlates of emotional action control in anger-prone women with borderline personality disorder. Journal of Psychiatry & Neuroscience: JPN, 43(3), 161-170
Bertsch, K., Roelofs, K., Roch, P. J., Ma, B., Hensel, S., Herpertz, S. C., & Volman, I.
(Siehe online unter https://doi.org/10.1503/jpn.170102) - (2018). Neurobiological mechanisms mediating emotion dysregulation as targets of change in borderline personality disorder. Psychopathology, 51(2), 96-104
Herpertz, S. C., Schneider, I., Schmahl, C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1159/000488357) - (2018). Neurobiology of Criterion A: self and interpersonal personality functioning. Current Opinion in Psychology, 21, 23-27
Herpertz, S. C., Bertsch, K., & Jeung, H.
(Siehe online unter https://doi.org/10.1016/j.copsyc.2017.08.032) - (2018). Out of control? Acting out anger is associated with deficient prefrontal emotional action control in male patients with borderline personality disorder. Neuropharmacology
Bertsch, K., Krauch, M., Roelofs, K., Cackowski, S., Herpertz, S. C., & Volman, I.
(Siehe online unter https://doi.org/10.1016/j.neuropharm.2018.12.010) - (2018). Remnants and changes in facial emotion processing in women with remitted borderline personality disorder: An EEG study. European Archives of Psychiatry and Clinical Neuroscience, 268(4), 429-439
Schneider, I., Bertsch, K., Hidalgo, N. A. I., Müller, L. E., Schmahl, C., & Herpertz, S. C.
(Siehe online unter https://doi.org/10.1007/s00406-017-0841-7) - (2019). Whole-brain functional connectivity during script-driven aggression in borderline personality disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93, 46-54
Ueltzhöffer, K., Herpertz, S. C., Krauch, M., Schmahl, C., & Bertsch, K.
(Siehe online unter https://doi.org/10.1016/j.pnpbp.2019.03.004)
